MRI Study of Tic Remission in Tourette Syndrome

This study is currently recruiting participants.
Verified June 2012 by University of Utah
Sponsor:
Information provided by:
University of Utah
ClinicalTrials.gov Identifier:
NCT01405859
First received: May 27, 2011
Last updated: June 1, 2012
Last verified: June 2012

May 27, 2011
June 1, 2012
January 2010
June 2012   (final data collection date for primary outcome measure)
Resting state functional connectivity [ Time Frame: Participants come in for a one-time visit. All participants will be enrolled by July 2012. Data will be analyzed by Sept 2012. ] [ Designated as safety issue: No ]
Quantitative measurements of integrated voxel-by-voxel blood oxygen level dependent fMRI time-series data will be compared between activated regions. Cross-correlation coefficients will be computed following band-pass filtering of data for evaluation of frequency-dependent contributions to correlation using standard functional connectivity techniques. Similar correlation analysis will be performed with signal from pulse oximetry and respiratory effort to evaluate for confounding stimulus-correlated physiological noise.
Same as current
Complete list of historical versions of study NCT01405859 on ClinicalTrials.gov Archive Site
Magnetic resonance spectroscopy [ Time Frame: Participants come in for a one-time visit. All participants will be enrolled by July 2012. Data will be analyzed by Sept 2012. ] [ Designated as safety issue: No ]
For each subject a central voxel within the anterior cingulate will be used as the region of interest. Peaks for substances of interest will be compared between each cohort.
Same as current
Not Provided
Not Provided
 
MRI Study of Tic Remission in Tourette Syndrome
Neuroimaging to Elucidate the Mechanism of Tic Resolution in Tourette Syndrome

Doctors provide a ray of hope to children and their parents with the knowledge that, for most patients, symptoms of Tourette syndrome improve by the time they are young adults. The investigators do not know why some improve and others do not. This study is designed to help answer that question. The investigators will use magnetic resonance imaging (MRI) techniques to test whether individuals who experience improvement of their Tourette's (tic remission) have more mature brain connections than those who do not.

One of the most interesting aspects of Tourette syndrome is a virtual remission of tics by early adulthood in about half of patients. Information is needed to clarify the mechanism of tic remission in order to guide development of better treatments for this disabling condition. For this cross-sectional study, 10 individuals with tic remission and 10 individuals with persistent Tourette syndrome are being recruited for a one-time study visit. 10 neurologically normal (non-TS) controls have also been recruited to obtain control neuroimaging data. All participants will complete a study questionnaire and a 60-minute MRI procedure. Sequences used to compare the groups will be volumetric, diffusion tensor, resting state functional connectivity MRI and MR spectroscopy. Our primary hypothesis is that the pattern of functional connectivity in individuals with tic remission will be more mature than that of those with persistent tics. Secondary hypotheses tested will explore whether the other modalities can be used to differentiate tic remission from persistent TS.

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample

Young adult males (aged 18-35) with a history of Tourette syndrome, including at least moderate disability from tics during childhood.

Tourette Syndrome
Not Provided
  • TS controls
  • Non TS Controls
  • TS remission
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
30
June 2012
June 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

All subjects: males aged 18-35 with history of Tourette syndrome and at least moderately disabling tics during childhood.

Persistent Tourette's subjects: history of disabling tics during childhood but no longer taking tic suppressing drugs.

Tic remission subjects: no longer experiencing any disability (even social discomfort) from tics. Must have had sustained improvement of tics for at least 3 years.

Normal controls: no longer recruiting.

Exclusion Criteria:

Tourette's subjects still taking tic suppressing drugs are excluded. Also excluded are any patients with a condition (such as a pacemaker, recent tattoo, implantable metal device, or claustrophobia) that could make the MRI examination unsafe.

Male
18 Years to 35 Years
Yes
Contact: David Shprecher 801-585-9386 David.Shprecher@hsc.utah.edu
United States
 
NCT01405859
39432
No
Assistant Professor David Shprecher, Neurology
University of Utah
Not Provided
Principal Investigator: David Shprecher Neurology
University of Utah
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP