Prevalence of Occult HBV Infection Among Anti-HBc Alone Group in Northern Taiwan

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by (Responsible Party):
Yi-Kuei Chen, Taipei Medical University WanFang Hospital
ClinicalTrials.gov Identifier:
NCT01396538
First received: July 4, 2011
Last updated: October 11, 2011
Last verified: October 2011

July 4, 2011
October 11, 2011
June 2011
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Complete list of historical versions of study NCT01396538 on ClinicalTrials.gov Archive Site
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Prevalence of Occult HBV Infection Among Anti-HBc Alone Group in Northern Taiwan
Prevalence of Occult HBV Infection Among Anti-HBc Alone Group in Northern Taiwan

Atni-HBs to HBsAg and Anit-HBc was interpreted based on three hepatitis markers for clinical detection of HBV-infections. HBAg and Anti-HBs were negative and the Anit-HBc-positive referred to as Anti-HBc alone. When the Anti-HBc alone occurs, patients may be due to mutations in HBV HBsAg can not be detected due to (1), but if by the molecular diagnostics by polymerase chain reaction (PCR) technology can detect HBV DNA present. When Anti-HBc alone in patients with serum HBV DNA can be measured, then there may be occult HBV infection. In different countries, Occult HBV infection in the Anti-HBc Alone group had significant differences in the prevalence (2.9 ~ 22.8%) (2), but prevalence survey in Taiwan there are very few studies on this , It is hoped to be able to investigation the prevalence of occult HBV infection Among Anti-HBc Alone.

The main use of this program, Taipei Medical University - Wan Fang Hospital in clinical specimens using the Roche system (Corbas e601) operating HBsAg, Anti-HBs, Anti-HBc to screen for the Anti-HBc alone group. Recycling Roche molecular system (Taq48) Real-time PCR to detect all anti-HBc alone population to understand their serum HBV-DNA viral load, in order to understand Occult HBV infection in the Anti-HBc alone group, the prevalence and viral load changes in these studies through the clinical units to provide occult HBV infection as a reference basis.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample

anti-HBc alone(HBsAg(-);Anti-HBs(-);Anti-HBc(+));occult HBV infection(the presence of HBV DNA in the liver and blood, in the absence Occult HBV of detectable HBsAg

HBV Coinfection
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
200
May 2012
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Inclusion Criteria:

HBsAg(-);Anti-HBs(-);Anti-HBc(+)

Exclusion Criteria:

None

Both
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No
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT01396538
100028
Yes
Yi-Kuei Chen, Taipei Medical University WanFang Hospital
Taipei Medical University WanFang Hospital
Not Provided
Study Director: Yi-Kue Chen, college Taipei Medical University WanFang Hospital
Taipei Medical University WanFang Hospital
October 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP