Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography

This study has been completed.
Sponsor:
Collaborator:
NHS Lothian
Information provided by (Responsible Party):
University of Edinburgh
ClinicalTrials.gov Identifier:
NCT01368237
First received: June 6, 2011
Last updated: October 27, 2014
Last verified: October 2014

June 6, 2011
October 27, 2014
May 2006
June 2014   (final data collection date for primary outcome measure)
Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software [ Time Frame: 1 month ] [ Designated as safety issue: No ]
The primary outcome measure is to establish whether 320-multidetector computed tomography can identify myocardial perfusion defects as compared to the gold standards of 3Tesla magnetic resonance imaging and fractional flow reserve measured during invasive coronary angiography.
Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software [ Time Frame: 1 month ] [ Designated as safety issue: No ]
The primary outcome measure is to establish whether 320-multidetector computed tomography can identify myocardial perfusion defects as compared to the gold standards of 3T magnetic resonance imaging and fractional flow reserve measured during invasive coronary angiography.
Complete list of historical versions of study NCT01368237 on ClinicalTrials.gov Archive Site
  • Identification of regional wall motion abnormalities qualitatively by trained observers [ Time Frame: 1 month ] [ Designated as safety issue: No ]
    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
  • Identification of infarction qualitatively by trained observers [ Time Frame: 1 month ] [ Designated as safety issue: No ]
    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
  • Identification of regional wall motion abnormalities quantitatively by computer software [ Time Frame: 1 month ] [ Designated as safety issue: No ]
    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
  • Identification of infarction qualitatively by computer software [ Time Frame: 1 month ] [ Designated as safety issue: No ]
    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
Identification of regional wall motion abnormalities, fibrosis and infarction qualitatively by trained observers and quantitatively by computer software [ Time Frame: 1 month ] [ Designated as safety issue: No ]
Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities, fibrosis and infarction in comparison to those obtained with 3T cardiac magnetic resonance imaging.
Not Provided
Not Provided
 
Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography
Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography

Recent advances in technology have resulted in the development of scanners that can image the heart blood vessels within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. Further advances in technology allow the visualisation of both the blood vessels and the supply of blood to the heart muscle. Here we propose to assess the latest and most powerful computed tomography scanner and compare it to magnetic resonance and conventional coronary angiography.

Not Provided
Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample

Patients awaiting invasive coronary angiography

Coronary Heart Disease
Radiation: Computed tomography scan
Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and imaging of myocardial perfusion, function and viability.
Patients
Patients awaiting invasive coronary angiography
Intervention: Radiation: Computed tomography scan
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
75
Not Provided
June 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • referred for invasive coronary angiography because of suspected coronary heart disease

Exclusion Criteria:

  • inability or unwillingness to undergo computed tomography or magnetic resonance imaging
  • renal failure (serum creatinine >200 micromol/L or estimated glomerular filtration rate <30 mL/min)
  • hepatic failure
  • allergy to iodinated contrast or gadolinium
  • pregnancy
  • contraindication to adenosine infusion
  • inability to give informed consent
  • inability to perform fractional flow reserve during invasive coronary angiography
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT01368237
210/R/CAR/11
No
University of Edinburgh
University of Edinburgh
NHS Lothian
Principal Investigator: David E Newby University of Edinburgh
University of Edinburgh
October 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP