Study of Trazodone & Cognitive Behavioral Therapy to Treat Insomnia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2011 by Milton S. Hershey Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Milton S. Hershey Medical Center
ClinicalTrials.gov Identifier:
NCT01348542
First received: April 20, 2011
Last updated: May 4, 2011
Last verified: April 2011

April 20, 2011
May 4, 2011
April 2011
April 2012   (final data collection date for primary outcome measure)
Change from Baseline in objective sleep duration at 9 months [ Time Frame: Baseline, 3 months & 9 months ] [ Designated as safety issue: No ]
Polysomnography & Actigraphy will be used to measure sleep duration at baseline, post treatment (3 months) and follow-up (9 months).
Same as current
Complete list of historical versions of study NCT01348542 on ClinicalTrials.gov Archive Site
Change from Baseline in Subjective Severity of Sleep Disturbance & Subjective Sleep Duration at 9 months [ Time Frame: Baseline, 3 months & 9 months ] [ Designated as safety issue: No ]
Sleep Diary and subjective questionnaires will be used to measure severity of sleep disturbance and subjective sleep duration at baseline, post treatment (3 months) and follow-up (9 months).
Same as current
Not Provided
Not Provided
 
Study of Trazodone & Cognitive Behavioral Therapy to Treat Insomnia
Efficacy of Trazodone vs. Cognitive Behavioral Therapy in Patients With Chronic Insomnia Associated With Objective Short Sleep Duration

The purpose of this study is to evaluate the effect of a 3 month medication trial of Trazodone versus 3 months of Cognitive Behavioral Therapy (CBT) in patients with chronic insomnia.

Participants with chronic insomnia associated with objective short sleep duration will be recruited to participate in a 3 month clinical trial on the efficacy of trazodone versus CBT. The primary outcome measure will be objective sleep duration as measured by both actigraphy and polysomnography. The secondary outcome measure will be subjective severity of sleep disturbance and subjective sleep duration.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Insomnia
  • Drug: Trazodone
    50 mg once a day, for 3 months
  • Behavioral: Cognitive Behavioral Therapy
    The CBT Protocol is implemented over a period of 12 weeks, with consultations held on a weekly basis.
  • Active Comparator: Trazodone
    Intervention: Drug: Trazodone
  • Active Comparator: Cognitive Behavioral Therapy
    Intervention: Behavioral: Cognitive Behavioral Therapy

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
24
Not Provided
April 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Chronic insomnia with duration of more than 1 year
  • Objective short sleep duration (< 6 hours)
  • BMI < 39
  • Ages 30-60
  • Men & Women

Exclusion Criteria:

  • Major Mental Illness
  • Substance Abuse/Dependence
  • Sleep Apnea
  • Periodic Limb Movement Disorder
  • Shift Work or circadian disorders
  • Diabetes
  • Chronic Renal Failure, Hepatic Insufficiency, Chronic Heart Failure
  • Current Use of hypnotics or sleep inducing sedative antidepressants
Both
30 Years to 60 Years
No
Contact: Carrie A Criley, BA, RPSGT 717 531-4123 ccriley@psu.edu
Contact: Julio Fernandez-Mendoza, PhD 717 531-0003 ext 285570 jfernandezmendoza@hmc.psu.edu
United States
 
NCT01348542
35933
No
Alexandros N. Vgontzas, MD, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center
Milton S. Hershey Medical Center
Not Provided
Principal Investigator: Alexandros N Vgontzas, MD Penn State College of Medicine, Penn State Milton S. Hershey Medical Center
Milton S. Hershey Medical Center
April 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP