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The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

This study has been completed.
Sponsor:
Information provided by:
Frederiksberg University Hospital
ClinicalTrials.gov Identifier:
NCT01346995
First received: May 2, 2011
Last updated: May 3, 2011
Last verified: February 2010

May 2, 2011
May 3, 2011
February 2010
August 2010   (final data collection date for primary outcome measure)
Isokinetic knee muscle strength [ Time Frame: At baseline and after 8 weeks of exercise ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01346995 on ClinicalTrials.gov Archive Site
One-leg chair rise [ Time Frame: At baseline and after 8 weeks of exercise ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain
The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Muscle Strength
  • Other: Experimental knee pain
    Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad
  • Other: Non-painful control injections
    Injection of isotonic saline into the infrapatellar fat pad
  • Experimental: Experimental Knee Pain
    Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad
    Intervention: Other: Experimental knee pain
  • Active Comparator: Control
    non-painful injections of isotonic saline into the infrapatellar fatpad.
    Intervention: Other: Non-painful control injections
Sørensen TJ, Langberg H, Hodges PW, Bliddal H, Henriksen M. Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: a randomized controlled trial. Arthritis Care Res (Hoboken). 2012 Jan;64(1):108-16. doi: 10.1002/acr.20618.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
36
August 2010
August 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • aged between 20 to 35 years
  • healthy
  • untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion Criteria:

  • symptomatic musculoskeletal diseases
  • history of traumatic injuries to muscles, tendons or joints of the lower extremity
  • knee joint pain within a month prior to enrollment
Both
20 Years to 35 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT01346995
072.07
No
Henning Bliddal, The Parker Institute
Frederiksberg University Hospital
Not Provided
Not Provided
Frederiksberg University Hospital
February 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP