Prognostic Value of Baseline Computed Tomography (CT) Perfusion Parameters of Pancreatic Cancer for Patients Undergoing Stereotactic Body Radiotherapy or Surgical Resection

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Stanford University
ClinicalTrials.gov Identifier:
NCT01326364
First received: April 14, 2010
Last updated: April 23, 2013
Last verified: April 2013

April 14, 2010
April 23, 2013
March 2010
June 2011   (final data collection date for primary outcome measure)
  • Histological markers of tumor angiogenesis (microvessel density, EGF/VEGF expression level) [ Time Frame: 1 day ] [ Designated as safety issue: No ]
  • Tumor response to treatment in SBRT patients, based on WHO criteria (No Change/Progressive Disease vs. Partial/Complete Response) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01326364 on ClinicalTrials.gov Archive Site
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Prognostic Value of Baseline Computed Tomography (CT) Perfusion Parameters of Pancreatic Cancer for Patients Undergoing Stereotactic Body Radiotherapy or Surgical Resection
Prognostic Value of Baseline CT Perfusion Parameters of Pancreatic Cancer for Patients Undergoing Stereotactic Body Radiotherapy or Surgical Resection

The purpose of this study is first, to determine whether baseline perfusion characteristics of pancreatic cancer, as characterized by CT perfusion studies, can predict tumor response to treatment by stereotactic body radiotherapy (SBRT). The second goal of this study is to determine whether baseline perfusion characteristics in those patients with resectable pancreatic cancer correlate with immunohistologic markers of angiogenesis such as microvessel density and vascular endothelial growth factor (VEGF) expression.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

pancreatic adenocarcinoma

Pancreatic Cancer
  • Procedure: Stereotactic body radiotherapy
    Standard of Care
    Other Name: CyberKnife
  • Drug: Iodixanol
    IV, calculated per patient
    Other Name: Visipaque
  • Drug: Iohexol
    IV, Calculated per patient
    Other Name: Omnipaque
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
50
September 2015
June 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. suspected and/or biopsy-proven pancreatic adenocarcinoma, and
  2. referral to Radiology for pre-treatment baseline pancreatic protocol CT.

Exclusion criteria:

1) are absolute contraindications to intravenous iodinated contrast or CT scan.

Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01326364
PANC0009, SU-03182010-5282
Yes
Stanford University
Stanford University
Not Provided
Principal Investigator: Aya Kamaya Stanford University
Stanford University
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP