Angina in Non Coronary Artery Disease (HeartQuest)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Prof. Paul Erne, Luzerner Kantonsspital
ClinicalTrials.gov Identifier:
NCT01318629
First received: March 17, 2011
Last updated: April 16, 2013
Last verified: April 2013

March 17, 2011
April 16, 2013
July 1996
July 2018   (final data collection date for primary outcome measure)
  • Cause of angina equivalent symptoms in patients with no coronary artery disease [ Time Frame: One day ] [ Designated as safety issue: No ]
  • Prognosis of patients with angina equivalent symptoms and normal coronary arteries [ Time Frame: 10 years after baseline assessment ] [ Designated as safety issue: No ]
  • Cause of angina equivalent symptoms in patients with no coronary artery disease [ Time Frame: At baseline during coronary angiography ] [ Designated as safety issue: No ]
  • Prognosis of patients with angina equivalent symptoms and normal coronary arteries [ Time Frame: 10 years after baseline assessment ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT01318629 on ClinicalTrials.gov Archive Site
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Angina in Non Coronary Artery Disease
Invasive Findings in Patients With Angina Equivalent Symptoms But No Coronary Artery Disease; Results From the Heart Quest Cohort Study

Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm.

All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study. Patients are extensively examined during angiography using acetylcholine infusion and fast atrial pacing. According to the result of the additional invasive examination (vasospasm, vasoconstriction, vasodilation; symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). Patients are followed-up after 10 years and prognosis of these patients is assessed (including mortality, cardiovascular events, re-angiography, functional status after 10 years).

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample

All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study.

  • Angina Pectoris
  • Microvascular Angina
  • Angina Pectoris, Variant
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Schoenenberger AW, Felber S, Gujer S, Moser A, Jamshidi P, Stuck AE, Erne P. Invasive findings in patients with angina equivalent symptoms but no coronary artery disease; results from the heart quest cohort study. Int J Cardiol. 2013 Jul 15;167(1):168-73. doi: 10.1016/j.ijcard.2011.12.053. Epub 2012 Jan 10.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
718
July 2018
July 2018   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008
  • No significant coronary stenoses (no coronary stenoses ≥ 50%)

Exclusion Criteria:

  • Severe valvular heart disease
  • Severe congestive heart failure
Both
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No
Contact information is only displayed when the study is recruiting subjects
Switzerland
 
NCT01318629
Heart Quest
No
Prof. Paul Erne, Luzerner Kantonsspital
Luzerner Kantonsspital
Not Provided
Principal Investigator: Paul Erne, MD Luzerner Kantonsspital
Luzerner Kantonsspital
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP