Stability of Middle Molecule Clearance (EMIC2)

• Clearance of Urea [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]
• Clearance of Cystatin C [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]
• Clearance of creatinine [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]
• Clearance of Beta2-Microglobulin [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]
• Clearance of Osteocalcin [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]
• Free light chains kappa of Immunoglobulins [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]
• Clearance of albumin [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]

• Mean arterial pressure [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]
• Vasopressor requirement [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]
• Heart rate [ Time Frame: up to 72 h ] [ Designated as safety issue: No ]

The investigators aim to show, whether all middle molecules are included in the clearance and whether this clearance is stable until 72 hours.

A better middle molecule clearance has been shown until 24 hours of duration. The investigators will extend our observations until 72 hours.

Patients of surgical intensive care unit

Inclusion Criteria:

• informed consent
• age>18 years
• acute renal insufficiency with indication for continuous hemodialysis, according to RILFE classification F: serum creatinine increase > 3-fold or serum creatinine > 4mg/dl with acute increase of >0,5mg/dl Urine Output <0,3mg/kg/h for 24 h or anuria for 12 h
• body weight:60-80kg
• anticoagulation with citrate possible and indicated
• Dose for hemodialysis of 2l/h

Exclusion Criteria:

• participation in another clinical trial within on month prior to this study
• pregnancy or brest feeding
• septic shock

• interference with cystatin-C

  1. haemolysis <1g/dl
  2. Bilirubin<9mg/dl
  3. Triglyceride >700mg/dl
  4. rheumatoid factor > 300kIU/l