Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2011 by National Cheng-Kung University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Cheng-Kung University Hospital
ClinicalTrials.gov Identifier:
NCT01281826
First received: January 20, 2011
Last updated: February 9, 2011
Last verified: January 2011

January 20, 2011
February 9, 2011
January 2011
December 2011   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01281826 on ClinicalTrials.gov Archive Site
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Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
Use of Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures

The purpose of this study is to

  1. Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference.
  2. Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual noncalcium images, such as the morphologic signs, visual qualitative detection, and quantitative values.

Patients with multiple compression fractures and in those with chronic fracture, determining which vertebra to treat is frequently difficult. In such patients, the treatment location is commonly determined from findings at imaging, which includes magnetic resonance (MR) imaging, bone scintigraphy, and computed tomography (CT).

The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra that is to be treated.

MR imaging provides information on anatomic vertebral collapse and the loss of normal T1 high signal intensity from the marrow space of vertebrae with acute fractures. Loss of normal T1 high signal intensity indicates the presence of BME, which is the important sign for the PVP treatment of VCFs.

Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine from contrast agent-enhanced CT examinations.We expect that the same technique can be used to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow accessible for CT diagnosis.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

Patients are recruited from Department of Orthopedics between january 2011 and december 2011.

  • Compression Fracture of Thoracic Vertebral Body
  • Spinal Compression Fracture
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
70
December 2011
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Compression fractures (thoracic and lumbar vertebrae)

Exclusion Criteria:

  • Age less than 18 years
  • Pregnancy
  • Any contraindications to MR imaging.
Both
18 Years to 75 Years
No
Contact: Chien-Kuo Wang 886-6-2353535 ext 2491 n044206@mail.hosp.ncku.edu.tw
Taiwan
 
NCT01281826
BR-99-093
Yes
Chien-Kuo Wang/Department of Diagnostic Radiology, National Cheng-Kung University Hospital
National Cheng-Kung University Hospital
Not Provided
Study Chair: Chien-Kuo Wang Department of Diagnostic Radiology Cheng Kung University Medicial Center
National Cheng-Kung University Hospital
January 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP