Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2010 by Kaplan Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Kaplan Medical Center
ClinicalTrials.gov Identifier:
NCT01278706
First received: January 18, 2011
Last updated: January 25, 2011
Last verified: December 2010

January 18, 2011
January 25, 2011
January 2011
January 2013   (final data collection date for primary outcome measure)
pregnancy rates [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01278706 on ClinicalTrials.gov Archive Site
live birth rates [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)
Comparing Timing and Number of Endometrial Biopsies in IVF Treatment and Identifying Biochemical Markers to Predict Endometrial Receptivity

Endometrial biopsy has been shown to improve IVF pregnancy and live birth rates. The optimal time of performing the biopsy is yet to be established.

In this study, the investigators will compare different temporal timing of the biopsies with regards to the menstrual cycle and their affect on the success rates of the treatment.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Infertility
  • Recurrent Implantation Failure
Procedure: endometrial biopsy/ies
performing office endometrial biopsy with a disposable sterile catheter
  • No Intervention: no treatment
  • Experimental: one biopsy, proliferative phase
    Intervention: Procedure: endometrial biopsy/ies
  • Experimental: one biopsy, secretory phase
    Intervention: Procedure: endometrial biopsy/ies
  • Experimental: two biopsies
    Intervention: Procedure: endometrial biopsy/ies
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
200
Not Provided
January 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • normal menstrual cycle
  • between 1-6 previous failed IVF cycles
  • normal hormonal profile

Exclusion Criteria:

  • intrauterine procedure in last 3 months
  • hydrosalpinx
  • intrauterine lesion /malformation
Female
18 Years to 38 Years
Yes
Contact: Dan Levin, M.D. +972-89441623 dan_l@clalit.org.il
Contact: Irit Granot, Ph.D. +972-8-9441623 irit_g@clalit.org.il
Israel
 
NCT01278706
kmc110154CTIL
Yes
Amihai Barash M.D. IVF Unit Director, Kaplan Medical Center
Kaplan Medical Center
Not Provided
Not Provided
Kaplan Medical Center
December 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP