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Impact of Genetic Polymorphisms on Dental Implant Loss

This study is currently recruiting participants.
Verified February 2013 by University Hospital, Ghent
Sponsor:
Information provided by (Responsible Party):
University Hospital, Ghent
ClinicalTrials.gov Identifier:
NCT01274442
First received: January 10, 2011
Last updated: February 1, 2013
Last verified: February 2013
History of Changes

January 10, 2011
February 1, 2013
June 2011
March 2013   (final data collection date for primary outcome measure)
genetic polymorphisms associated with implant loss [ Time Frame: after 3 to 6 years ] [ Designated as safety issue: No ]
Identification of genetic polymorphisms that are associated with implant loss. It concerns only one evaluation (1 blood sample).
Same as current
Complete list of historical versions of study NCT01274442 on ClinicalTrials.gov Archive Site
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Impact of Genetic Polymorphisms on Dental Implant Loss
A Case-control Study on the Impact of Genetic Polymorphisms on Dental Implant Loss.

Patients that may participate in this case-control study underwent dental implant surgery in the University Hospital in Ghent in 2004-2007.

According to one of our recent papers based on this patient group, 34/461 patients lost one or more implants. The goal is to invite these 34 patients, to update the anamnesis, to perform a brief clinical oral examination and to have a blood sample. The latter is necessary to identify relevant genetic polymorphisms of the patient that are associated with implant loss. Among the remaining patients that did not lose implants, another 34 'controls' will be invited for the same examinations.
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Interventional
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Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Patients Treated by Means of 1 or More Dental Implants
  • Other: anamnesis
    To update the anamnesis.
  • Procedure: oral examination
    A brief clinical oral examination will be performed.
  • Procedure: Blood sample
    A blood sample will be taken to identify relevant genetic polymorphisms.
  • Active Comparator: CONTROL: no dental implants lost
    Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, who did not lose their implants.
    Interventions:
    • Other: anamnesis
    • Procedure: oral examination
    • Procedure: Blood sample
  • Experimental: CASE: patients lost one or more implants
    Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, but who lost one or more implants.
    Interventions:
    • Other: anamnesis
    • Procedure: oral examination
    • Procedure: Blood sample
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
68
March 2013
March 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Dental implant surgery in the University Hospital in Ghent in 2004-2007.
  • Case: dental implant loss
  • Control: no dental implant loss

Exclusion Criteria:

-
Both
18 Years and older
No
Contact: Elisabeth De Wilde, Dentist Elisabeth.DeWilde@ugent.be
Belgium
 
NCT01274442
2010/771
No
University Hospital, Ghent
University Hospital, Ghent
Not Provided
Principal Investigator: Hugo De Bruyn, MD, PhD University Hospital, Ghent
University Hospital, Ghent
February 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP