Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients

This study is enrolling participants by invitation only.
Sponsor:
Information provided by:
Shanghai Jiao Tong University School of Medicine
ClinicalTrials.gov Identifier:
NCT01271634
First received: January 5, 2011
Last updated: July 22, 2011
Last verified: July 2011

January 5, 2011
July 22, 2011
January 2011
December 2011   (final data collection date for primary outcome measure)
Abnormal Potential From the Offending Vessel to the Facial Muscles [ Time Frame: up to 4 months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01271634 on ClinicalTrials.gov Archive Site
Latency from the root entry zone of facial nerve to the facial muscles [ Time Frame: up to 4 months ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients
Observation of the Abnormal Potential From the Offending Vessel to the Facial Muscles of Hemifacial Spasm Patients

The pathophysiologic basis of hemifacial spasm is cross-transmission between different branches of the facial nerve. The hypothesis is that the cross-transmission is mediated by the sympathetic nerve fibers on the surface of the offending artery. The abnormal potential from the offending vessel to the facial muscles will be detected on hemifacial spasm patients, so as to determine if the sympathetic nerve fibers take part in the circuit of cross-transmission.

It's hypothesized that at the location where the facial nerve is compressed by an artery, ephaptic cross-transmission takes place between the nude facial nerve fibers and the sympathetic nerve fibers on the arterial surface. Thus action potentials could spread indirectly from one facial nerve fiber to several other facial nerve fibers (via the "bridge" of sympathetic fibers), or directly from the sympathetic fibers to facial nerve fibers. The investigators assume this is the electrophysiological basis of hemifacial spasm and its characteristic sign abnormal muscle response (AMR). If an abnormal potential from the offending artery to the facial muscles similar to AMR can be recorded, the hypothesis will be verified.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

This study will enroll 20 cases of hemifacial spasm patients who want to undergo microvascular decompression.

Hemifacial Spasm
Not Provided
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Møller AR, Jannetta PJ. On the origin of synkinesis in hemifacial spasm: results of intracranial recordings. J Neurosurg. 1984 Sep;61(3):569-76.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Enrolling by invitation
20
December 2011
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. the age of 18-65 years old;
  2. with typical hemifacial spasm symptoms;
  3. with typical abnormal muscle response;
  4. preoperative magnetic resonance imaging revealed obvious paraneural artery;
  5. with informed consent.

Exclusion Criteria:

  1. pregnant or lactating women;
  2. accompanied by other serious diseases, including liver, kidney, cardiovascular diseases;
  3. accompanied by mental illness or severe neurosis;
  4. unable to express the subjective symptoms.
Both
18 Years to 65 Years
No
Contact information is only displayed when the study is recruiting subjects
China
 
NCT01271634
xzheng-hfs-1
No
Xuesheng Zheng, XinHua Hospital, Affiliated to Shanghai JiaoTong University School of Medicine
Shanghai Jiao Tong University School of Medicine
Not Provided
Principal Investigator: Xuesheng Zheng, M.D. XinHua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai Jiao Tong University School of Medicine
July 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP