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Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations (RESCUE)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
American College of Radiology Imaging Network
ClinicalTrials.gov Identifier:
NCT01262625
First received: December 15, 2010
Last updated: May 29, 2013
Last verified: May 2013

December 15, 2010
May 29, 2013
January 2011
August 2014   (final data collection date for primary outcome measure)
Outcomes Comparison Between Group A and Group B Diagnostic Tests [ Time Frame: up to 24 Months (depends on time of trial enrollment and funding duration) ] [ Designated as safety issue: Yes ]
To compare outcomes of participants with symptoms of stable angina or angina equivalent evaluated with an anatomic imaging strategy using CCTA as initial method of CAD diagnosis (Group A) to a combined functional and anatomic imaging strategy of SPECT MPI/ICA (Group B) as a guide to OMT.
Same as current
Complete list of historical versions of study NCT01262625 on ClinicalTrials.gov Archive Site
  • Evaluate Prognostic Indices to Predict Outcomes [ Time Frame: 24 Months ] [ Designated as safety issue: No ]
    To evaluate the ability of available prognostic indices to predict revascularization or MACE using CCTA information and to develop new indices using the RESCUE trial data.
  • Cost, Effectiveness, and Incremental Cost-Effectiveness [ Time Frame: 6 and 12, and possibly 18 and 24 Months ] [ Designated as safety issue: No ]
    To determine the cost, effectiveness, and incremental cost-effectiveness of CCTA versus SPECT MPI/ICA in the evaluation of participants with symptoms of stable angina.
  • Outcomes Related to Symptoms and Self-Reported Health Status [ Time Frame: 6 and 12, and possibly 18 and 24 Months ] [ Designated as safety issue: Yes ]
    To compare angina symptoms and self-reported health status of participants with symptoms of stable angina undergoing CCTA as initial method of CAD diagnosis to SPECT MPI/ICA as a guide to OMT.
Same as current
Not Provided
Not Provided
 
Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations
ACRIN 4701 RESCUE: Randomized Evaluation of Patients With Stable Angina Comparing Utilization of Diagnostic Examinations

This randomized, controlled, diagnostic, multicenter trial will compare two diagnostic imaging pathways--coronary computed tomography angiography (CCTA) and single photon emission tomography (SPECT) myocardial perfusion imaging (MPI)--to determine the incidence of major adverse coronary events (MACE), defined as myocardial infarction (MI) or cardiac-related death, and cross-over to revascularization. CCTA may be used to direct patients with symptoms of stable angina or angina equivalent to optimal medical therapy (OMT). The use of CCTA as a diagnostic tool for angina symptoms will be associated with no increase in MACE or revascularization, decreased cost, reduced risks (e.g., less radiation exposure), additional insights into alternate explanations of chest pain, and increased cost-effectiveness in comparison with use of SPECT MPI/invasive coronary angiography (ICA).

The Randomized Evaluation of Patients with Stable Angina Comparing Utilization of Diagnostic Examinations (RESCUE) is a multi-center randomized, controlled trial responding to the need for comparative analysis of these imaging technologies and the role of OMT in clinical care. A total of 4300 patients will be randomized to CCTA or SPECT MPI/ICA for diagnostic assessment of angina at up to 80 institutions internationally. This study builds on the results of the COURAGE trial by comparing CCTA and SPECT MPI/ICA integrated into a care paradigm featuring initial treatment with OMT for patients diagnosed with CAD without significant disease in the left main coronary artery. Participants will be followed for a composite endpoint of MACE and cross-over to revascularization over a follow-up period up to two years (two to six time points depending on diagnostic results and time of enrollment into the trial). The primary endpoint of the study is a combined endpoint of occurrence of MACE and revascularization. We will calculate differences in the combined MACE/revascularization endpoint between the CCTA and SPECT MPI/ICA arms. Participant outcomes will be assessed by age, gender, comorbidity, and angina classification class at presentation. Several comparative-effectiveness analyses will be performed. We hypothesize that the CCTA arm will be associated with no increase in MACE or revascularization, decreased cost, reduced risks (e.g., less radiation exposure), additional insights into or alternate explanations of chest pain, and increased cost-effectiveness in comparison with SPECT MPI/ICA. Findings are expected to result in validation of an evolving new standard of care for patients with stable angina that takes advantage of CCTA and OMT to more cost-effectively drive appropriate care while reducing the need for invasive diagnosis and increased radiation exposure with SPECT MPI/ICA.

Interventional
Phase 3
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
  • Chest Pain
  • Stable Angina Pectoris, CCS Class I to III
  • Angina Equivalent
  • Coronary Artery Disease
  • Device: CCTA
    Complete diagnostic CCTA per protocol specifications.
    Other Names:
    • coronary CT
    • cardiac CT
  • Device: SPECT MPI/ICA
    Perform SPECT MPI per institutional standard practice; diagnostic ICA will be performed only as indicated per protocol.
    Other Names:
    • nuclear medicine cardiac stress test
    • stress test
    • nuclear medicine stress testc
    • cardiac stress test
    • exercise cardiac stress test
    • pharmacologic cardiac stress test
  • Experimental: Group A: CCTA Diagnostic
    Participants randomized to diagnostic evaluation using CCTA to determine therapeutic course of action.
    Intervention: Device: CCTA
  • Active Comparator: Group B: SPECT MPI/ICA Diagnostic
    Standard-of-care diagnostic assessment using SPECT MPI, possibly followed by diagnostic ICA dependent on SPECT MPI results.
    Intervention: Device: SPECT MPI/ICA

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
4300
Not Provided
August 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Willing and able to provide a written informed consent;
  • 40 years or older;
  • Presentation with symptoms of stable angina (CCS Class I to III) or angina equivalent with or without known CAD;
  • Planned non-invasive imaging for CAD diagnosis;
  • Able to tolerate CCTA or SPECT MPI per randomization as required by protocol, to be performed at an ACRIN-qualified facility with a RESCUE-qualified scanner.

Exclusion Criteria:

  • Prior revascularization;
  • Not suitable to undergo CT with an iodinated contrast agent:

    • Known allergy-like reaction to contrast media as defined by the American College of Radiology (ACR) (see www.acr.org/SecondaryMainMenuCategories/quality_safety/contrast_manual.aspx for reaction definition) or moderate to severe allergic reactions to more than one allergen;
    • Renal failure, as determined by glomerular filtration rate (GFR) < 30 mL/min/1.73 m2 based on a serum creatinine level obtained within 28 days prior to registration;
  • Renal insufficiency at the time of enrollment, as determined by GFR 30 to 60 mL/min/1.73 m2 based on a serum creatinine level obtained within 28 days prior to registration, unless permitted by the institution's policy and/or ACR guidance for risk reduction strategies (see www.acr.org/SecondaryMainMenuCategories/quality_safety/contrast_manual.aspx for guidance on contrast selection and pre-treatment strategies);
  • Atrial fibrillation or significant arrhythmia judged to potentially limit quality of CCTA;
  • Acute ischemia;
  • Acute myocardial infarction;
  • Severe myocardial ischemia: known markedly positive exercise treadmill stress test (significant ST segment depressions or hypotensive response during stage I of the Bruce protocol);
  • Unable to suspend respiration for 15 seconds or to follow instructions to do so;
  • Unstable angina and symptoms refractory to maximal oral and intravenous medical therapy (persistent CCS Class IV);
  • History of known left ventricular ejection fraction < 45%;
  • Pulmonary edema or heart failure unresponsive to standard medical therapy;
  • Pacemaker;
  • Valvular heart disease likely to require surgery in the next 18 months;
  • Congenital heart disease or cardiomyopathy likely to affect prognosis during follow up;
  • Significant systemic hypertension (blood pressure > 200/100 mm Hg) unresponsive to medical therapy;
  • Severe noncardiovascular comorbidity limiting survival (e.g., cancer or other life threatening illness for which the patient is expected to live less than 12 months);
  • Prior imaging evaluation for this episode of symptoms (e.g., SPECT MPI or CCTA within the previous 72 hours);
  • BMI > 40 kg/m2;
  • Pregnancy or intent to become pregnant (if a female is of childbearing potential—defined as a premenopausal female capable of becoming pregnant—a pregnancy test should be done prior to enrollment).
Both
40 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01262625
ACRIN 4701: RESCUE, 1R01HS019403
Yes
American College of Radiology Imaging Network
American College of Radiology Imaging Network
Not Provided
Study Chair: Arthur Stillman, MD, PhD Division of Cardiothoracic Imaging, Emory University
Principal Investigator: Pamela K Woodard, MD Mallinckrodt Institute of Radiology, Washington University of Medicine
American College of Radiology Imaging Network
May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP