Expanding Rapid Ascertainment Network of Schizophrenia Families in Taiwan

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2010 by China Medical University Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
National Taiwan University Hospital
Information provided by:
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01249079
First received: November 24, 2010
Last updated: November 30, 2010
Last verified: October 2010

November 24, 2010
November 30, 2010
October 2010
December 2013   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01249079 on ClinicalTrials.gov Archive Site
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Expanding Rapid Ascertainment Network of Schizophrenia Families in Taiwan
Expanding Rapid Ascertainment Network of Schizophrenia Families in Taiwan

This proposal responds to Request for Applications RFA-MH-08-131, which seeks applications that propose to enrich pre-existing resources for schizophrenia in the National Institute of Mental Health (NIMH) Human Genetics Initiative and to apply genomic methods to further the investigators understanding of the molecular etiology of the disorder. The overarching aims of this proposal are to quickly and cost-effectively ascertain a large sample of trio families affected by schizophrenia, and to discover causal variants for the disorder in the first family-based genome-wide association study (GWAS) of the disorder. In Taiwan, there is no such kind of policy to support this kind of GWAS study as it is a very expensive study, including collecting large family samples and genome-wide single-nucleotide polymorphism (SNP) scanning. The investigators, thus, collaborate with Professor Ming T, Tsuang and his entended subcontracted researchers to apply for this project. The investigators, the research team in Taiwan, will collect 3800 trio families (11400 subjects) of schizophrenia. Through additional ascertainment within this framework, the investigators will collect an aggregate sample with adequate power for detecting in a GWAS those variants that make even small contributions to the risk for the disorder.

The investigators will meet the overarching goals of this project by accomplishing several Specific Aims, as follows: 1) Rapidly ascertain schizophrenia trio families from Taiwanese clinical ascertainment sites; 2) Supplement NIMH Genetics Initiative collections by sending all clinical data and biomaterials to the appropriate repositories; 3) Assess the association of schizophrenia with a genome-wide panel of single-nucleotide polymorphisms (SNPs) and their constituent haplotypes; 4) Analyze quantitative schizophrenia phenotypes such as age at onset ; 5) Perform a genome-wide survey for copy-number variations related to schizophrenia; 6) Test for gene-gene interactions (epistasis); and 7) Test for gene-environment interactions, such as the well-established effect of season of birth.

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Observational
Observational Model: Family-Based
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Non-Probability Sample

Schizophrenia patients and their biological parents

Schizophrenia
Other: No intervention would be provided in this research
No intervention would be provided in this research,but need to draw blood
Schizophrenia Family
Intervention: Other: No intervention would be provided in this research
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
600
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December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • clinical diagnosis of schizophrenia and their parents, and parents are still alive

Exclusion Criteria:

  • person with Mental Retardation
  • persons with epilepsy
  • alcohol or substance abuse combined
  • in combination with other organic brain damage syndrome
Both
16 Years to 90 Years
Yes
Contact: Hai-Gwo Hwu 886-2-23122453 ext 66785 haigohwu@ntu.edu.tw
Taiwan
 
NCT01249079
DMR99-IRB-214
Not Provided
Hsien-Yuan Lane,Chief of Psychiatry Department, China Medical University Hospital
China Medical University Hospital
National Taiwan University Hospital
Study Director: Hsien-Yuan Lane China Medical University Hospital
China Medical University Hospital
October 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP