Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC (ARversusNAR)

This study is not yet open for participant recruitment.
Verified October 2010 by University of Milan
Sponsor:
Information provided by:
University of Milan
ClinicalTrials.gov Identifier:
NCT01236989
First received: October 29, 2010
Last updated: November 8, 2010
Last verified: October 2010

October 29, 2010
November 8, 2010
January 2011
December 2017   (final data collection date for primary outcome measure)
the prognostic impact of anatomical resection by means of intraoperative ultrasound (IOUS) guided vessel compression versus nonanatomical resection in terms of disease free and overall survival [ Time Frame: 5-years ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01236989 on ClinicalTrials.gov Archive Site
the impact of anatomical resection versus non-anatomical resection in terms of postoperative mortality and morbility [ Time Frame: 30 and 90 days ] [ Designated as safety issue: Yes ]
Same as current
Not Provided
Not Provided
 
Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC
Anatomical Liver Resection by Means of Ultrasound-guided Vessel Compression Versus Non-anatomical Resection for Hepatocellular Carcinoma: A Randomized Controlled Trial

Prognostic impact of AR vs NAR

Whether anatomical is better than non anatomical resection for HCC is still debated. This prospective randomized study aimed to address which approach is better in terms of patients prognosis.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Patients Affected by Hepatocellular Carcinoma
  • Disease-Free Survival
  • Overall Survival
  • Procedure: anatomical liver resection
    anatomical liver resection by means of IOUS-finger compression
  • Procedure: Non-anatomical liver resection
    non-anatomical liver resection
  • Experimental: Anatomical resection
    Intervention: Procedure: anatomical liver resection
  • Active Comparator: Non-anatomical resection
    Intervention: Procedure: Non-anatomical liver resection

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
120
December 2017
December 2017   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • patient affected by single HCC
  • patients in whom liver resection is indicated
  • HCC without vascular invasion and/or thrombosis

Exclusion Criteria:

  • multinodular HCC
  • metastatic disease
  • spontaneous tumor rupture
Both
Not Provided
No
Contact: Guido Torzilli, MD, PhD +39 02 8224 ext 4083 guido.torzilli@unimi.it
Italy
 
NCT01236989
AR vs NAR
Yes
Guido Torzilli, MD, PhD, Liver Surgery Unit, 3rd Department of Surgery, University of Milan School of Medicine, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
University of Milan
Not Provided
Principal Investigator: Guido Torzilli, MD, PhD IRCCS Istituto Clinico Humanitas, Milan, Italy
University of Milan
October 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP