Liver Regeneration After Liver Resection

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2010 by Nottingham University Hospitals NHS Trust.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Nottingham University Hospitals NHS Trust
ClinicalTrials.gov Identifier:
NCT01220986
First received: October 13, 2010
Last updated: NA
Last verified: October 2010
History: No changes posted

October 13, 2010
October 13, 2010
August 2010
December 2011   (final data collection date for primary outcome measure)
Not Provided
Not Provided
No Changes Posted
Not Provided
Not Provided
Not Provided
Not Provided
 
Liver Regeneration After Liver Resection
An Observational Study of Liver Regeneration After Right Hepatectomy: Understanding the Molecular Primers of Liver Regeneration

The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Liver tissue & serum

Non-Probability Sample

Patients undergoing right hepatectomy for colorectal liver metastases.

  • Liver Diseases
  • Hepatectomy
Procedure: Liver biopsy
0, 30, 60, 90 min post inflow-division
Right hepatectomy
Intervals from inflow division.
Intervention: Procedure: Liver biopsy
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
20
August 2012
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients requiring right hepatectomy for colorectal liver metastases

Exclusion Criteria:

  • Age >75, neoadjuvant chemotherapy, recurrent disease
Both
18 Years to 75 Years
No
Contact: John S Hammond, BM.BS PhD 01159249924 ext 70607 john.hammond@nottingham.ac.uk
United Kingdom
 
NCT01220986
NDDC10/H0403/32
Yes
John S. Hammond, Division of Surgery, NIHR Nottingham Digestive Diseases Centre BRU
Nottingham University Hospitals NHS Trust
Not Provided
Study Chair: Dileep N. Lobo, DM FRCS Reader in Surgery
Nottingham University Hospitals NHS Trust
October 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP