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A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2010 by The University of Hong Kong.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
The University of Hong Kong
ClinicalTrials.gov Identifier:
NCT01217346
First received: October 4, 2010
Last updated: October 7, 2010
Last verified: October 2010
History of Changes

October 4, 2010
October 7, 2010
February 2009
December 2012   (final data collection date for primary outcome measure)
apnea hypopnea index [ Time Frame: measure at a single time point when the subjects are admitted for overnight polysomnography ] [ Designated as safety issue: No ]
assess apnea hypopnea index by overnight polysomnography, by a single admission to sleep laboratory
Same as current
Complete list of historical versions of study NCT01217346 on ClinicalTrials.gov Archive Site
endothelial function [ Time Frame: measured at a single time point when the subjects are admitted for overnight polysomnography ] [ Designated as safety issue: No ]
assess endothelial function by EndoPAT 2000 (an non-invasive device) and peripheral blood endothelial progenitor cells
Same as current
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A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram
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Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction. Endothelial dysfunction is also reported to be linked to obstructive sleep apnea. While chest pain can be one of potential presenting symptoms of obstructive sleep apnea, the investigators hypothesize that obstructive sleep apnea is common in subjects with cardiac syndrome X.
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Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
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Non-Probability Sample

Subjects with chest pain, positive exercise treadmill test and normal coronary angiogram
  • Obstructive Sleep Apnea
  • Cardiac Syndrome X
  • Endothelial Dysfunction
Other: no intervention is involved in this study
no intervention is involved in this study
cardiac syndrome X
subjects fulfilling the clinical triad of cardiac syndrome X
Intervention: Other: no intervention is involved in this study

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
100
Not Provided
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age ≧18 years, < 70 years
  • Symptom of chest pain occurring at least once in the preceding year
  • Positive exercise treadmill test
  • Negative coronary angiogram
  • Mentally fit to give informed consent

Exclusion Criteria:

  • Mentally incapacitated persons
  • Congestive heart failure
  • Other potential causes of orthopnea (severe chronic obstructive pulmonary disease, persistent asthma)
Both
18 Years to 70 Years
No
Contact: Macy MS Lui, MBBS, MRCP 852-22554455 macylui@graduate.hku.hk
Hong Kong
 
NCT01217346
UW 09-127
Yes
Lui Mei Sze Macy, Queen Mary Hospital, The University of Hong Kong
The University of Hong Kong
Not Provided
Principal Investigator: Macy MS Lui Queen Mary Hospital, The University of Hong Kong
The University of Hong Kong
October 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP