Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2010 by Xijing Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
Fourth Military Medical University
Xi’an Jiaotong University College of Medicine
Information provided by:
Xijing Hospital
ClinicalTrials.gov Identifier:
NCT01201655
First received: September 13, 2010
Last updated: NA
Last verified: January 2010
History: No changes posted

September 13, 2010
September 13, 2010
January 2010
December 2012   (final data collection date for primary outcome measure)
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No Changes Posted
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Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis
Multicentric Retrospective Case Control Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis

The purpose of this study is to investigate the impact of splenectomy coupled with portal-azygous disconnection on hepatocarcinogenesis in patients with post-hepatitic cirrhosis after hepatitis B or C virus infection by retrospective case-control study,We hope to find a new idear and method to prevent or cure HCC.

A case-control study was carried out. The factors studied include age, gender, ascites, hepatic encephalopathy, ALT, AST, TBIL, ALP, GGT, Child-Pugh classification of liver function, and history of splenectomy with portal-azygous disconnection during the treatment of portal hypertension. According to the Child-Pugh classification, these cases were graded as A, B, and C. And according to the ranges of the normal reference values of the data, they were categorized into two groups including a normal group and an abnormal group.The data mainly comes from FMMU and Xi'an jiaotong university from the year of 2002 to 2012.

Observational
Observational Model: Case Control
Time Perspective: Retrospective
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Probability Sample

post-hepatitic cirrhosis with portal hypertension and hypersplenism patients

  • Liver Cirrhosis
  • Carcinoma, Hepatocellular
  • Splenomegaly
  • Laparotomy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
5000
December 2012
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • after surgery

Exclusion Criteria:

  • without surgery
Both
20 Years to 90 Years
No
Contact: Chen yong, professor 13891915509 cheny@fmmu.edu.cn
China
 
NCT01201655
chenyong
Yes
chen yong, Xijing Hospital
Xijing Hospital
  • Fourth Military Medical University
  • Xi’an Jiaotong University College of Medicine
Study Director: Chen yong, professor Xia jielai
Xijing Hospital
January 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP