MEDIR Medulloblastome

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2010 by University Hospital, Grenoble.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University Hospital, Grenoble
ClinicalTrials.gov Identifier:
NCT01197924
First received: September 7, 2010
Last updated: September 8, 2010
Last verified: September 2010

September 7, 2010
September 8, 2010
October 2007
July 2012   (final data collection date for primary outcome measure)
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Not Provided
Complete list of historical versions of study NCT01197924 on ClinicalTrials.gov Archive Site
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MEDIR Medulloblastome
Médulloblastome of the Child and After-effects Cognitive: Study Anatomo-functional by IRM of the Working Memory

The medulloblastome is a tumour of the child relatively frequent usually sitting in the cerebellum and treated by surgery, radiotherapy and chemotherapy. After the treatment, these children present cognitive disorders and in particular disorders of the working memory associated with a fall with the school performances. By studying a troop of 32 children, we could show that the disorders of the working memory prevail during the handling of information presented visually and with verbal contents. However, the specific engagement of the cerebellum in the tasks of working memory according to the sensory method of presentation (visual or auditive) and the nature (verbal or not verbal) of information to treat vague remainder. Moreover, the anatomical attacks associated with these disorders remain ignored in these children. The best comprehension of the bases anatomo-functional calculuses which underlie their cognitive deficits is essential to develop new strategies of treatment and rehabilitation.

Objectives:

  • To describe in IRMf of the common and specific networks engaged during the execution of the tasks of working memory according to the sensory type and the nature of information to be memorized.
  • To describe in IRMf the cortical reorganizations necessary to the execution of the mnemic tasks among patients.
  • To describe in anatomical IRM and of the tensor of diffusion lesions cérébelleuses and cerebral, cortical and subcortical associated with these disorders.
  • To study the correlations radio-private clinics between data IRM and the data neurological and neuropsychological of the children explored according to protocol ONCORAP

The functional study should make it possible to show the specifically committed networks according to the cognitive tasks. Among patients, the relative difficulty to carry out the tasks of working memory should be accompanied by a recruitment of the dorso-side cortex préfrontal, lower and parietal frontal cortex but also of the median frontal areas such as the additional driving surface, the former cingulum. Moreover, one deterioration of the engagement of the cérébello-cerebral network (left lower parietal cortex and cérébelleux cortex lower right) facilitating the execution of these tasks should be observed.

Observational
Observational Model: Case Control
Not Provided
Not Provided
Non-Probability Sample

child Treaties for a médulloblastome after the 6 years age

Child Cancer Brain
Other: IRMf Bold
IRMf BOLD of the working memory
  • healthy volonteer children
    paired for the sex and the age
    Intervention: Other: IRMf Bold
  • older children followed for a médulloblastome cérébelleux
    children followed for a médulloblastome treaty by surgery, radiotherapy and chemotherapy
    Intervention: Other: IRMf Bold
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
80
July 2012
July 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Old from 8 to 12 years
  • Total IQ > 70 for the participation in the study and/or age développemental 7 years minimum
  • Treaties for a médulloblastome after the 6 years age in remission supplements with 6 months a minimum time compared to the end of all the treatments
  • Followed within the framework of the protocol of evaluation of the mnemic and attentionnelles after-effects
  • Sensory after-effects compatible with the realization of the tasks and good performances at the time of the preceding drive the IRM
  • Absence of counter-indication to the IRM
  • Absence of catch of méthylphénidate (Ritaline®) for the treatment of disorders attentionnels 48h before the IRM
  • Enlightened assent signed by at least one of the two parents or holders of the parental authority and by the child (minor)

Exclusion Criteria:

  • Agitation or movements of the head at the time the IRM
  • Artifacts of magnetic susceptibility in projection of the areas of interest (intracranial haemorrhage, cortical and/or metal remains post-operative) • Bad execution of the cognitive tasks
  • Tumoral relapse in the course of protocol
Both
8 Years to 12 Years
Yes
Contact: Isabelle I SCHIFF 0476762635 ISchiff@chu-grenoble.fr
France
 
NCT01197924
07PHN01
No
PAGNIER Anne, Professor, Pédiatrie
University Hospital, Grenoble
Not Provided
Principal Investigator: Anne A PAGNIER, Doctor University Hospital, Grenoble
University Hospital, Grenoble
September 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP