Evaluation of Surfactant Protein B in the Differential Diagnostics of Dyspnea

This study has been completed.
Sponsor:
Collaborator:
Roche Diagnostics AG, Switzerland
Information provided by (Responsible Party):
Joachim Saur, University Hospital Mannheim
ClinicalTrials.gov Identifier:
NCT01197586
First received: September 8, 2010
Last updated: June 21, 2013
Last verified: June 2013

September 8, 2010
June 21, 2013
October 2010
December 2011   (final data collection date for primary outcome measure)
Surfactant protein B serum levels [ Time Frame: Days 1, 3 and 7 ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT01197586 on ClinicalTrials.gov Archive Site
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Evaluation of Surfactant Protein B in the Differential Diagnostics of Dyspnea
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Establishing new biochemical markers in the differential diagnostics and risk stratification in heterogeneous patient collectives is becoming more and more important. The markers should be objective, reliable, reproducible, quick and cost effective as well as specific and sensitive. Concerning the differential diagnostics of "dyspnea", NT-pro-BNP plays the most important role for the evaluation of a cardiac origin. However, a corresponding biochemical marker for pulmonary stress is lacking. The aim of the study at hand therefore was the evaluation of surfactant protein B in the differential diagnostics of pulmonary and cardiac diseases.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample

patients presenting with the symptom "dyspnea" in a university hospital emergency room

  • Dyspnea
  • Cardiac Disease
  • Pulmonary Disease
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
55
December 2011
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • patients presenting with dyspnea and giving informed consent

Exclusion Criteria:

  • outpatients
  • lack or doubt of legal competence
  • indication for mechanical ventilation
  • pregnancy
  • palliative patients
  • CPAP/LTOT
  • BMI > 30 kg/m2
  • sepsis
  • anemia
  • dialysis
Both
18 Years to 80 Years
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
NCT01197586
2010_spb_ma
Yes
Joachim Saur, University Hospital Mannheim
Universitätsmedizin Mannheim
Roche Diagnostics AG, Switzerland
Principal Investigator: Joachim Saur, MD Universitätsmedizin Mannheim
Universitätsmedizin Mannheim
June 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP