Transformation of Somatosensory and Visual Coordinate Systems

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2013 by Chang Gung Memorial Hospital
Sponsor:
Information provided by (Responsible Party):
Yu-Cheng Pei, Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier:
NCT01177462
First received: July 29, 2010
Last updated: September 23, 2013
Last verified: September 2013

July 29, 2010
September 23, 2013
March 2011
December 2014   (final data collection date for primary outcome measure)
Perceived direction of tactile motion [ Time Frame: Once; specifically for stroke patients, 6 months after the onset of stroke ] [ Designated as safety issue: No ]

Detail description for time frame of assessment:

(1) for stroke patients, the assessment will be performed "in average" 6 months after the onset of stroke (2) for normal subjects: assessment will be done when the subject is willing to participate (3) the subject might come to the lab more than once if the experiment can not be completed in one session

Assessment:

We present tactile motion using tactile stimulators to (1)different digits (2)different hand conformations and (3) different hand positions relative to the trunk

Same as current
Complete list of historical versions of study NCT01177462 on ClinicalTrials.gov Archive Site
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Transformation of Somatosensory and Visual Coordinate Systems
The Transformation of Coordinates Between Somatosensory and Visual Systems: a Neurophysiological Study

Manipulation of object is a multisensory experience that includes tactile motion between the object and the fingerpad, visual motion elicited by the motion the object and the movement of the hand, and the active motor commend to control upper limb and hand conformation. It remains to be determined how such a complex interaction between touch and vision could be achieved effortlessly. In the present study, we will investigate how the motion information is transformed between touch and vision using the most novel approaches in human psychophysics, neuropsychology and monkey neurophysiology. Specifically, we will present tactile motion on primate fingerpads using a recently developed ball stimulator with a design in which we vary the direction of motion with respect to the skin surface and also vary the hand conformation and position. This setup allows us to systematically sample the possible scenarios involving coordinate transformation between the somatosensory and visual systems in conditions that could occur in hand exploration and object manipulation in daily life. We will present these tactile stimuli on normal human subject as well as stroke patients such as patients with spatial hemineglect. Finally, we will record from macaque monkeys in cortical areas that are thought to underlie the transformation of coordinates, such as the primary somatosensory cortex and posterior parietal cortex. The results of the present study will contribute to the understanding of multisensory integration and the rehabilitation for patients with impaired use of spatial information.

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Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Non-Probability Sample

We will recruit 40 normal healthy adult subjects (equal to and more than 18 years old); the exclusion criteria are subjects with brain pathology, peripheral neuropathy and limb amputation. We will also recruit 50 stroke patients, the including criteria are stroke patients with stable medical condition and being capable of receiving the evaluations. In this group, stroke patients with peripheral neuropathy, and unstable medical condition.

Stroke
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  • hemineglect stroke patients
    Stroke patients with hemineglect
  • Control stroke patients
    Stroke patients without hemineglect
  • Normal control
    Normal subjects
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
90
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December 2014   (final data collection date for primary outcome measure)

For stoke patients

Inclusion Criteria:

  • stroke patients
  • stable medical condition
  • can cooperate in evaluation

Exclusion Criteria:

  • peripheral neuropathy
  • limb ambulation
Both
18 Years and older
Yes
Taiwan
 
NCT01177462
CMRPG590021G
Yes
Yu-Cheng Pei, Chang Gung Memorial Hospital
Chang Gung Memorial Hospital
Not Provided
Principal Investigator: Yu-Cheng Pei, MD PhD Chang Gung Memorial Hospital
Chang Gung Memorial Hospital
September 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP