Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

This study has been completed.
Sponsor:
Collaborators:
National Research Agency, France
Solvay Pharmaceuticals
Information provided by:
Institut National de la Recherche Agronomique
ClinicalTrials.gov Identifier:
NCT01154608
First received: June 30, 2010
Last updated: NA
Last verified: May 2010
History: No changes posted

June 30, 2010
June 30, 2010
April 2005
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transfer of dietary nitrogen to metabolic pools [ Designated as safety issue: Yes ]
Same as current
No Changes Posted
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Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis
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Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.

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Interventional
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Allocation: Randomized
Intervention Model: Crossover Assignment
Primary Purpose: Basic Science
Pancreatitis
  • Drug: Creon
  • Other: No enzyme therapy
    Current enzyme therapy of the patient is stopped during 7 days
  • Experimental: pancreatic enzymes
    Intervention: Drug: Creon
  • Placebo Comparator: control
    Intervention: Other: No enzyme therapy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
11
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Inclusion Criteria:

  • Chronic pancreatitis
  • Pancreatic insufficiency
  • Enzyme therapy treatment

Exclusion Criteria:

  • Hepatic failure
  • Pregnancy
  • Positive serology to HIV, HCV, AGHbS, gastro-intestinal disease
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
France
 
NCT01154608
PANCREATITE
Yes
Pr Benamouzig, Assistance Publique - Hôpitaux de Paris
Institut National de la Recherche Agronomique
  • National Research Agency, France
  • Solvay Pharmaceuticals
Not Provided
Institut National de la Recherche Agronomique
May 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP