Relative Efficacy of Vitamins D2 and D3 in Adult Humans

This study has been completed.
Sponsor:
Collaborators:
Health Future Foundation
BTR Group
Information provided by (Responsible Party):
Creighton University
ClinicalTrials.gov Identifier:
NCT01139840
First received: June 7, 2010
Last updated: October 27, 2011
Last verified: October 2011

June 7, 2010
October 27, 2011
January 2010
August 2010   (final data collection date for primary outcome measure)
AUC for increment in serum 25(OH)D [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01139840 on ClinicalTrials.gov Archive Site
change in vitamin D content of subcutaneous fat [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Relative Efficacy of Vitamins D2 and D3 in Adult Humans
Vitamin D Status: Relative Efficacy of Vitamins D2 and D3

Vitamin D2 in chronic dosing will produce less of an elevation of serum 25(OH)D than will the same dose of vitamin D3.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Bio-equivalence Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Prevention
Healthy
  • Dietary Supplement: vitamin D2
    Study Supplement
  • Dietary Supplement: vitamin D3
    Study Supplement
  • Active Comparator: vitamin D2
    Intervention: Dietary Supplement: vitamin D2
  • Active Comparator: vitamin D3
    Intervention: Dietary Supplement: vitamin D3
Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab. 2011 Mar;96(3):E447-52. doi: 10.1210/jc.2010-2230. Epub 2010 Dec 22.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
32
September 2010
August 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • willingness to withhold supplement use for duration of study
  • willingness to avoid sun exposure for duration of study

Exclusion Criteria:

  • vitamin D supplement use
  • conditions that affect vitamin D metabolism by the body
Both
21 Years to 65 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01139840
09-15612
No
Creighton University
Creighton University
  • Health Future Foundation
  • BTR Group
Principal Investigator: Robert P Heaney, MD Creighton University
Creighton University
October 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP