Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Karen Wood, Ohio State University
ClinicalTrials.gov Identifier:
NCT01135706
First received: May 20, 2010
Last updated: October 31, 2012
Last verified: October 2012

May 20, 2010
October 31, 2012
April 2010
February 2012   (final data collection date for primary outcome measure)
FD of the pulmonary artery in patients with PH will be lower when compared to patients without PH. [ Time Frame: 24 Months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01135706 on ClinicalTrials.gov Archive Site
  • FD will correlate with the degree of PH as quantified by the MPAP obtained during RHC. [ Time Frame: 24 Months ] [ Designated as safety issue: No ]
  • FD will correlate with the functional capacity of the PH patients as quantified by distance during six-minute walk and NYHA functional class. [ Time Frame: 24 Months ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension
Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension.

The investigators propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

Pulmonary hypertension (PH) is an insidious disorder that can occur in isolation or as a result of various other pulmonary and systemic conditions. If left untreated PH may progress to right heart failure and death. Numerous tests are suggestive but not diagnostic of PH including cardiac echo, pulmonary function testing and chest x-ray. Definitive diagnosis requires right heart catheterization that is invasive, costly and time consuming. The fractal dimension (FD) is an index of the space-filling properties of an object so that the closer the dimension is to the topological dimension in which the object is embedded, the greater the space filling properties. No investigations have been performed to analyze the fractal dimension of pulmonary arteries in patients with PH. We propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

Observational
Observational Model: Cohort
Time Perspective: Retrospective
Not Provided
Not Provided
Non-Probability Sample

Patients having a right heart catheterization and CT pulmonary angiogram

Pulmonary Hypertension
Other: No Intervention
This study does not include an intervention but is observational in nature.
  • Pulmonary Hypertension
    Patients having a right heart catheterization and CT pulmonary angiogram with a diagnosis of Pulmonary Hypertension
    Intervention: Other: No Intervention
  • Non Pulmonary Hypertension
    Patients having a right heart catheterization and CT pulmonary angiogram without a diagnosis of Pulmonary Hypertension.
    Intervention: Other: No Intervention
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
6
February 2012
February 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients having a right heart catheterization and CT pulmonary angiogram

Exclusion Criteria:

  • None
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01135706
2010H0097
No
Karen Wood, Ohio State University
Ohio State University
Not Provided
Principal Investigator: Karen Wood, M.D. Ohio State University
Ohio State University
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP