The Immune Tolerance Mechanism Induced by IL-17-producing Regulatory T Cells in the Orthotopic Liver Transplant Recipients With Aspergillosis

This study is enrolling participants by invitation only.
Sponsor:
Information provided by:
Shanghai Jiao Tong University School of Medicine
ClinicalTrials.gov Identifier:
NCT01117077
First received: May 4, 2010
Last updated: NA
Last verified: May 2010
History: No changes posted

May 4, 2010
May 4, 2010
May 2010
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The Immune Tolerance Mechanism Induced by IL-17-producing Regulatory T Cells in the Orthotopic Liver Transplant Recipients With Aspergillosis
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Infection accounted for the first cause of death in patients after liver transplantation, and 2 / 3 of the cause of death was fungal infections. The investigators group early found that T cell subsets playing a role of inducing immune tolerance were significantly increased in vivo of liver transplantation patients with aspergillus infection, which may be a kind of Treg cells expressing IL-17. To explore the immune tolerance mechanism induced by the immune balance cells is important to liver transplantation patients for improving efficacy and reducing the mortality. Therefore, the investigators are going to get the blood sample and liver tissue of the liver transplantation patients before and after treatment of aspergillus infection, flow cytometry analysis of blood T cell subsets, Cytometric Bead Array to detect changes in blood cytokines, laser capture microdissection to obtain liver biopsies of inflammatory cells in portal area and further for analysis of T cell subsets and protein. And the investigators are also to investigate the characteristics of CCR6 + CD4 + FOXP3 + Treg cell clones secreting IL-17 and the capacity of which suppressing conventional T cell proliferation. This study may find new methods, such as certain types of T cell subsets or cytokines for the treatment of liver transplant patients, which not only to anti-rejection but also to reduce fungal infection.

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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Probability Sample

liver transplantation patients with aspergillus infection or without aspergillus infection

  • Liver Transplantation
  • Aspergillus
  • Interleukin-17
  • Treg Cell
  • Immune Tolerance
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Enrolling by invitation
50
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Inclusion Criteria:

Liver transplantation patients

Exclusion Criteria:

Psychopath

Both
18 Years to 65 Years
No
Contact information is only displayed when the study is recruiting subjects
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NCT01117077
10ZR1423900
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Shanghai First People's Hospital
Shanghai Jiao Tong University School of Medicine
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Shanghai Jiao Tong University School of Medicine
May 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP