Study Comparing CT Scan and Stress Test in Patients With Known Coronary Artery Disease Hospitalized for Chest Pain (PROSPECT-CAD)

This study has been terminated.
(low recruitment)
Sponsor:
Collaborator:
Albert Einstein College of Medicine of Yeshiva University
Information provided by (Responsible Party):
Jeffrey Levsky, Montefiore Medical Center
ClinicalTrials.gov Identifier:
NCT01106612
First received: April 12, 2010
Last updated: December 18, 2013
Last verified: December 2013

April 12, 2010
December 18, 2013
April 2010
June 2014   (final data collection date for primary outcome measure)
Number of participants that undergo subsequent cardiac catheterization but do not have consequent coronary angioplasty, stenting or bypass [ Time Frame: 3 months ] [ Designated as safety issue: Yes ]
Same as current
Complete list of historical versions of study NCT01106612 on ClinicalTrials.gov Archive Site
  • Length of hospital stay (time to discharge) [ Time Frame: 1 month ] [ Designated as safety issue: No ]
  • Number of participants that have a subsequent non-fatal myocardial infarction [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
  • Number of participants that die due to any cause [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
  • Number of participants that experience a procedural complication due to non-invasive imaging, cardiac catheterization or coronary revascularization [ Time Frame: 3 months ] [ Designated as safety issue: Yes ]
Same as current
Not Provided
Not Provided
 
Study Comparing CT Scan and Stress Test in Patients With Known Coronary Artery Disease Hospitalized for Chest Pain
A Randomized Controlled Trial Comparing Coronary CT Angiography and Radionuclide Stress Myocardial Perfusion Imaging in Symptomatic Inpatients With Known Coronary Artery Disease

The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with known coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
  • Coronary Artery Disease
  • Angina Pectoris
  • Unstable Angina
  • Acute Coronary Syndrome
  • Procedure: Coronary CT angiography
    EKG-gated, computed tomography angiography of the coronary arteries during heart rate control
    Other Names:
    • Coronary CTA
    • Coronary CT
    • CTA of the coronary arteries
    • CT of the coronary arteries
    • CTA
    • CCTA
    • Cardiac CTA
    • Cardiac CT
    • CT Angiography of the coronary arteries
    • Computed tomography angiography of the coronary arteries
  • Procedure: Myocardial perfusion imaging
    Stress radionuclide myocardial perfusion imaging
    Other Names:
    • MPI
    • MPS
    • stress MPI
    • stress MPS
    • radionuclide MPI
    • stress nuclear
    • nuclear stress
    • nuclear stress test
    • nuclear stress testing
    • nuclear cardiology
    • nuclear perfusion imaging
    • nuclear myocardial perfusion imaging
    • myocardial perfusion
  • Experimental: Initial coronary CT angiography
    EKG-gated, computed tomography angiography of the coronary arteries during heart rate control
    Intervention: Procedure: Coronary CT angiography
  • Active Comparator: Initial nuclear stress test
    Stress radionuclide myocardial perfusion imaging
    Intervention: Procedure: Myocardial perfusion imaging
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
7
July 2014
June 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • patient admitted for chest pain / pressure or other suggestive symptoms
  • patient has known coronary artery disease (with or without prior revascularization)
  • patient has clinical need for non-invasive cardiac evaluation

Exclusion Criteria:

  • evidence of ongoing myocardial infarction or hemodynamic instability
  • ischemia on EKG (greater than 1mm ST segment deviation)
  • contraindications to CT scanning with iodinated intravenous contrast (including allergies, asthma and renal dysfunction)
  • heart rhythm precluding EKG gating
  • pregnancy
Both
21 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01106612
MMC-07-07-197-a26
Yes
Jeffrey Levsky, Montefiore Medical Center
Montefiore Medical Center
Albert Einstein College of Medicine of Yeshiva University
Study Director: Linda B Haramati, MD, MS Montefiore Medical Center / Albert Einstein College of Medicine
Principal Investigator: Jeffrey M Levsky, MD, PhD Montefiore Medical Center / Albert Einstein College of Medicine
Montefiore Medical Center
December 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP