Effects of Strength Training in Combination With Endurance Training on Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease (COPD)

This study has been completed.
Sponsor:
Information provided by:
Medical University of Vienna
ClinicalTrials.gov Identifier:
NCT01091623
First received: March 23, 2010
Last updated: NA
Last verified: May 2005
History: No changes posted

March 23, 2010
March 23, 2010
June 2005
January 2010   (final data collection date for primary outcome measure)
increase of exercise capacity
Same as current
No Changes Posted
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Effects of Strength Training in Combination With Endurance Training on Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease (COPD)
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Background. Exercise intolerance is one of the most devastating consequences of chronic obstructive pulmonary disease (COPD). Abnormalities in peripheral muscle function such as weakness and reduction in oxidative enzyme activities are commonly found in these patients and may contribute to exercise intolerance.To evaluate whether a systemic weightlifting exercise may improve exercise capacity better than endurance training, or a combined training is more effective, the investigators compared three different training regimens, endurance training alone, systemic weightlifting training alone or a combination of both endurance and weightlifting training.

Methods.36 patients with stable COPD will be evaluated before and after a 4 month training program. Each evaluation include a stepwise exercise test on an ergocycle up to the individual maximal capacity during which minute ventilation (VE), oxygen consumption (VO2), carbon dioxide production (VCO2), and arterial lactic acid concentration will be measured and the peripheral muscle strength will be determined with the one repetition maximum for eight different muscle groups. Percutaneous needle muscle biopsy from the M.vastus lateralis will be performed before and after the training period in order to determine the fiber-type proportions. Patients are assigned to one of the following three groups (1) endurance training consisted of 20 min exercise sessions on a calibrated ergocycle two times a week, with a target training intensity at 60% of individual maximum oxygen uptake, (2) systemic weightlifting training two times a week with eight different exercises, each session consist of 15 repetitions of each muscle group, (3) combination of endurance training and systemic weightlifting training.

Statistical analysis. Baseline data for all patients enrolled in the study will be compared by one-way analysis of variance for the three study groups. Results before and after training will be analyzed by two- way analysis of variance.

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Interventional
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Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Chronic Obstructive Pulmonary Disease
Other: training
  • Active Comparator: strength training
    Intervention: Other: training
  • Active Comparator: endurance training
    Intervention: Other: training
  • Active Comparator: combined training
    Intervention: Other: training
Vonbank K, Strasser B, Mondrzyk J, Marzluf BA, Richter B, Losch S, Nell H, Petkov V, Haber P. Strength training increases maximum working capacity in patients with COPD--randomized clinical trial comparing three training modalities. Respir Med. 2012 Apr;106(4):557-63. doi: 10.1016/j.rmed.2011.11.005. Epub 2011 Nov 26.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
36
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January 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. age: 40-75 years
  2. mild to moderate COPD patients according to the staging schemata of the austrian society of lung and tuberculosis disease (ÖGLUT)

Exclusion Criteria:

  1. acute infection
  2. reduced left ventricular function
  3. myocardial infarction
  4. stroke
  5. severe pulmonary hypertension (mpap>40mmHg)
  6. insufficient treated hypertension RR>160/95) (participation with sufficient treatment )
  7. severe cardiac arrhythmia
  8. malignant diseases
  9. severe osteoporosis
  10. nicotine abuses
  11. other severe chronic diseases
Both
40 Years to 75 Years
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Contact information is only displayed when the study is recruiting subjects
Austria
 
NCT01091623
001/2005
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Medical University of Vienna
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Medical University of Vienna
May 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP