Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2010 by University of Malaya.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Malaysian Society of Anaesthesiologists
Information provided by:
University of Malaya
ClinicalTrials.gov Identifier:
NCT01083953
First received: March 8, 2010
Last updated: March 9, 2010
Last verified: March 2010

March 8, 2010
March 9, 2010
November 2009
April 2010   (final data collection date for primary outcome measure)
Optimal end tidal concentration of sevoflurane/ desflurane [ Time Frame: 6 months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01083953 on ClinicalTrials.gov Archive Site
presence of airway response [ Time Frame: 10 mins after surgery ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults
Optimal End-Tidal Concentration of Sevoflurane and Desflurane for Removal of Supreme Laryngeal Mask Airway in Anaesthetized Adults

The purpose of this study is to determine the optimal volatile anaesthetic (sevoflurane and desflurane) to remove a Supreme LMA in adults in which there is minimal airway response.

Null hypothesis: there is no significant difference between the optimal end tidal concentration of sevoflurane and desflurane for Supreme LMA removal.

The manufactures' instructions for removal of the LMA recommend waiting until protective reflexes have returned. However, the appropriate timing for removal remains controversial. A more frequent incidence of airway hyperreactivity and complications has been reported by some studies when the LMA was removed in the awake state versus the anesthetized state. Techniques that reduce the time from LMA removal to the return of protective airway reflexes would minimize the risk of aspiration, contamination, or airway obstruction.

With increasingly common use of Supreme LMA in anaesthetic practice, a safe and suitable depth for removal of the Supreme LMA requires research.

Thus the determination of the optimal end-tidal concentration of commonly used volatile agents ie. Sevoflurane and Desflurane for Supreme LMA removal requires research, both for patient safety and minimising anaesthetic costs in dealing with airway complications.

Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Supportive Care
Airway Complications
  • Drug: Sevoflurane
    Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation
  • Drug: Desflurane
    Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation
  • Experimental: Sevoflurane
    1 arm will receive sevoflurane at varying concentrations at which extubation is attempted according to the Dixon up and down method
    Intervention: Drug: Sevoflurane
  • Experimental: Desflurane
    1 arm will receive desflurane at varying end tidal concentration at which extubation will be attempted according to Dixon up and down method
    Intervention: Drug: Desflurane
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
70
June 2010
April 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. ASA 1-2 patients
  2. Age 18 - 49 years old
  3. Elective surgery of short duration ( < 2 hours ) which require local anaesthetic infiltration

Exclusion Criteria:

  1. Upper respiratory tract symptoms in the previous 10 days
  2. Risk of gastric oesophageal reflux or regurgitation
  3. Known or predicted difficult airway
  4. Poor dentition with high risk of damage
  5. BMI > 30 kg/m2
  6. Refusing to participate
Both
18 Years to 49 Years
Yes
Contact: Cindy Thomas Joseph +60122067060 cindytj@gmail.com
Contact: Wang Chew Yin +60192340232 wangcy1836@gmail.com
Malaysia
 
NCT01083953
supreme sevo vs des
No
Dr Cindy Thomas Joseph, Department of Anaesthesiology, University of Malaya
University of Malaya
Malaysian Society of Anaesthesiologists
Principal Investigator: Cindy Thomas Joseph Department of Anaesthesiology, UMMC
University of Malaya
March 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP