Vitamin D and Zinc Levels in Patients Undergoing Ergometry Test

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2010 by Assaf-Harofeh Medical Center.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Assaf-Harofeh Medical Center
ClinicalTrials.gov Identifier:
NCT01080274
First received: March 3, 2010
Last updated: April 6, 2010
Last verified: February 2010

March 3, 2010
April 6, 2010
March 2010
March 2011   (final data collection date for primary outcome measure)
positive stress test [ Time Frame: one year ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01080274 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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Vitamin D and Zinc Levels in Patients Undergoing Ergometry Test
Vitamin D and Zinc Levels in Patients Undergoing Ergometry Test

Low vitamin D levels were found to be associated with cardiovascular morbidity and mortality. Low zinc levels are associated with an increased atherosclerotic burden. Therefore we hypothesized that patients with pathological stress test would have low levels of Vitamin D and zinc compared to patients with a normal stress test.

Hypovitaminosis D is generally defined as 25(OH)D levels of < 20ng/ml, while levels of 21-29ng/ml indicate insufficiency and those above 30ng/ml are regarded as sufficient.

The rational behind the observations associating vitamin D deficiency with CVD is that on the one hand, hypovitaminosis D was found to be associated with traditional risk factors such as hypertension (HTN),diabetes mellitus (dm),obesity, dyslipidemia and metabolic syndrome , on the other hand, experimental data demonstrated that vitamin D could affect cardiac muscle cells directly, control parathyroid (PTH) hormone secretion, regulate the rennin- angiotensin- aldosterone system and the immune system, all of which could influence cardiovascular risk.

Epidemiological studies further support this association, demonstrating high prevalence of hypovitaminosis D among U.S. adults with cardiovascular disease (74%). An association between low vitamin D levels and increased myocardial infarction risk as well as total mortality has been also observed.

Low 25hydroxyvitamin D[ 25(OH)D] levels were also independently associated with all cause and CVD mortality among patients scheduled for coronary catheterization.

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples Without DNA
Description:

blood will be collected for vit d and zinc , stored until all samples are collected and only than the laboratoty will analyze it.

Non-Probability Sample
  • Over 18 years old
  • CCT > 60 ml/min
  • No IHD
  • No hyper/hypoparathyroidism
  • No active malignancy
  • Not taking calcium, phosphate
Atherosclerosis
Not Provided
  • positive ergometry
    positive ergometry as specified by a cardiologist on site.
  • negative ergometry.
    negative ergometry as specified by cardiologist on site.
  • patients with positive stress test
    100 patients with positive ergometry test as specified by the cardiologist in charge. All patients are ambulatory patients referred for routine check up.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
200
March 2011
March 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Over 18 years old
  • CCT > 60 ml/min
  • No IHD
  • No hyper/hypoparathyroidism
  • No active malignancy
  • Not taking calcium, phosphate

Exclusion Criteria:

  • Under 18 years of age
  • Not fulfilling inclusion criteria
Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
Israel
 
NCT01080274
22/10
No
Renana Shor MD, Assaf-Harofeh Medical Center
Assaf-Harofeh Medical Center
Not Provided
Not Provided
Assaf-Harofeh Medical Center
February 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP