Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction

This study has been completed.
Sponsor:
Collaborators:
University Hospital St Luc, Brussels
University Hospital Sart Tilman, Liege
University of Lausanne Hospitals
Notre Dame de Grace Hospital, Gosselies
Information provided by:
University Hospital, Geneva
ClinicalTrials.gov Identifier:
NCT01074866
First received: February 23, 2010
Last updated: September 20, 2012
Last verified: January 2010

February 23, 2010
September 20, 2012
July 2010
December 2010   (final data collection date for primary outcome measure)
Patient-ventilator synchronization parameters [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01074866 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction
The Effects of Neurally Adjusted Ventilatory Assist (NAVA) on Improving Patient-ventilator Interaction in Patients Undergoing Ventilation for Acute Respiratory Failure

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin.

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin. The subgroup of COPD patients will be analyzed separately. The effects of various setting of Neurally adjusted ventilatory assist on patient-ventilator interaction will also be explored.

Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Supportive Care
  • Non Invasive Ventilation
  • Patient Ventilator Interaction
Device: Neurally Adjusted Ventilatory Assist
Non invasive ventilation under Neurally adjusted Ventilatory Assist
Other Name: NAVA
  • No Intervention: Pressure support
    Non invasive ventilation under pressure support (PS)
  • Active Comparator: Neurally Adjusted Ventilatory Assist
    Non invasive ventilation under Neurally Adjusted ventilatory Assist
    Intervention: Device: Neurally Adjusted Ventilatory Assist
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
13
December 2011
December 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients admitted to the ICU and treated with Non invasive ventilation for acute respiratory failure of any origin

Exclusion Criteria:

  • severe hypoxemia requiring an FIO2>0.6
  • hemodynamic instability
  • known oesophageal problem
  • active upper gastro-intestinal bleeding
  • any other contraindication to the insertion of a naso-gastric tube
  • impaired consciousness or absence of patient cooperation
  • facial or laryngeal lesions contraindicating the use of NIV
  • poor short term prognosis
Both
18 Years to 90 Years
No
Contact information is only displayed when the study is recruiting subjects
Belgium,   Switzerland
 
NCT01074866
NAVA_NIV
No
Intensive Care Unit, HUG, University hospital of Geneva
University Hospital, Geneva
  • University Hospital St Luc, Brussels
  • University Hospital Sart Tilman, Liege
  • University of Lausanne Hospitals
  • Notre Dame de Grace Hospital, Gosselies
Study Director: Didier Tassaux, MD HUG, University hospital Geneva
University Hospital, Geneva
January 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP