A Study That Will Evaluate Ketogenesis and Glucose-Dependent Insulin Secretion Methodologies in Healthy Male Subjects

• Ambient plasma glucose concentration during the GGI [ Time Frame: Last 160 minutes of OXM/placebo infusion ] [ Designated as safety issue: No ]
• plasma βOHB + AcAc concentrations [ Time Frame: First 300 minutes of OXM/placebo infusion ] [ Designated as safety issue: No ]

This study will test the hypotheses that a single dose of oxyntomodulin (OXM) will be neutral or better than placebo in lowering ambient glucose levels during a graded glucose infusion (GGI) and that a single dose of OXM will lead to a statistically significant increase in the sum of the plasma βOHB + AcAc levels compared to placebo.

• Drug: Oxyntomodulin (OXM)
  Single infusion of OXM 3.0 pmol/kg/min by IV
• Drug: Comparator: Oxyntomodulin (OXM)
  Single infusion of OXM 0.6 pmol/kg/min by IV
• Drug: Comparator: Placebo [ hemaccel-containing saline]
  Single Placebo infusion of hemaccel-containing saline by IV

• Experimental: Treatment sequence 1
  OXM 3.0 pmol/kg/min - OXM 0.6 pmol/kg/min - Placebo
  Interventions:

  • Drug: Oxyntomodulin (OXM)
  • Drug: Comparator: Oxyntomodulin (OXM)
  • Drug: Comparator: Placebo [ hemaccel-containing saline]
• Experimental: Treatment sequence 2
  OXM 0.6 pmol/kg/min - Placebo - OXM 3.0 pmol/kg/min
  Interventions:

  • Drug: Oxyntomodulin (OXM)
  • Drug: Comparator: Oxyntomodulin (OXM)
  • Drug: Comparator: Placebo [ hemaccel-containing saline]
• Experimental: Treatment sequence 3
  Placebo - OXM 3.0 pmol/kg/min - OXM 0.6 pmol/kg/min
  Interventions:

  • Drug: Oxyntomodulin (OXM)
  • Drug: Comparator: Oxyntomodulin (OXM)
  • Drug: Comparator: Placebo [ hemaccel-containing saline]
• Experimental: Treatment sequence 4
  OXM 3.0 pmol/kg/min - Placebo - OXM 0.6 pmol/kg/min
  Interventions:

  • Drug: Oxyntomodulin (OXM)
  • Drug: Comparator: Oxyntomodulin (OXM)
  • Drug: Comparator: Placebo [ hemaccel-containing saline]
• Experimental: Treatment sequence 5
  Placebo - OXM 0.6 pmol/kg/min - OXM 3.0 pmol/kg/min
  Interventions:

  • Drug: Oxyntomodulin (OXM)
  • Drug: Comparator: Oxyntomodulin (OXM)
  • Drug: Comparator: Placebo [ hemaccel-containing saline]
• Experimental: Treatment sequence 6
  OXM 0.6 pmol/kg/min - OXM 3.0 pmol/kg/min - Placebo
  Interventions:

  • Drug: Oxyntomodulin (OXM)
  • Drug: Comparator: Oxyntomodulin (OXM)
  • Drug: Comparator: Placebo [ hemaccel-containing saline]

Inclusion Criteria:

• Subject is judged to be in good health based on medical history, physical examination, and laboratory safety tests
• Subject has a Body Mass Index of ≥27 kg/m^2 and ≤35 kg/m^2 and weighs ≥70 kg at the prestudy (screening) visit
• Subject has been a nonsmoker and/or has not used nicotine or nicotine-containing products for at least approximately 6 months
• Subject is willing to avoid strenuous physical activity (weight lifting, running, bicycling, etc.) for the duration of the study

Exclusion Criteria:

• Subject is mentally or legally incapacitated, has significant emotional problems at the time of prestudy (screening) visit
• Subject has a history of stroke, chronic seizures, or major neurological disorder
• Subject has a history of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, or genitourinary abnormalities or diseases
• Subject has irritable bowel disease, or recurrent occurrences of nausea, vomiting, diarrhea, or abdominal pain
• Subject has a history of hypertension requiring treatment
• Subject has a history of cancer
• Subject has history of diabetes, or family history of diabetes mellitus
• Subject has a history of hypersensitivity to OXM or hemaccel