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Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Haukeland University Hospital
ClinicalTrials.gov Identifier:
NCT01044979
First received: December 17, 2009
Last updated: July 3, 2014
Last verified: July 2014

December 17, 2009
July 3, 2014
December 2009
September 2010   (final data collection date for primary outcome measure)
Colloid osmotic pressure [ Time Frame: 60 and 90 minuttes after implanting wicks ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT01044979 on ClinicalTrials.gov Archive Site
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Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma
Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma, a Methodological Study

The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.

Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples Without DNA
Description:

Serum and interstitial fluid

Non-Probability Sample

Healthy volunteers over 18 years.

Colloid Osmotic Pressure
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Guthe HJ, Nedrebø T, Tenstad O, Wiig H, Berg A. Effect of topical anaesthetics on interstitial colloid osmotic pressure in human subcutaneous tissue sampled by wick technique. PLoS One. 2012;7(2):e31332. doi: 10.1371/journal.pone.0031332. Epub 2012 Feb 14.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
50
September 2010
September 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Adults over 18 years

Exclusion Criteria:

  • Ongoing illness
  • Medication
Both
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Yes
Contact information is only displayed when the study is recruiting subjects
Norway
 
NCT01044979
071223
No
Haukeland University Hospital
Haukeland University Hospital
Not Provided
Principal Investigator: Hans Joergen T Guthe, MD Haukeland University Hospital
Haukeland University Hospital
July 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP