Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

This study has been completed.
Sponsor:
Collaborators:
Korea Healthcare Technology R&D Project
Korea Advanced Institute of Science and Technology
Information provided by:
Chungnam National University
ClinicalTrials.gov Identifier:
NCT01025024
First received: December 2, 2009
Last updated: NA
Last verified: December 2009
History: No changes posted

December 2, 2009
December 2, 2009
January 2007
October 2009   (final data collection date for primary outcome measure)
genotyping for the SNP associated with primary open angle glaucoma [ Time Frame: one year ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns [ Time Frame: one year ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients
Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients Patients, A Single-nucleotide Polymorphism(SNP)Analysis for Primary Open Angle Glaucoma

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Peripheral blood sample

Non-Probability Sample

patients with open angle glaucoma who visited glaocoma clinic of departemtn of Ophtalmology, Chungnam National University Hospital, Daejeon, south Korea

Single-nucleotide Polymorphism (SNP) for Glaucoma
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
  • POAG group
    Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect
    Intervention: Genetic: SNP analysis of the DNA
  • Normal control
    Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease
    Intervention: Genetic: SNP analysis of the DNA
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
1224
November 2009
October 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Clinical diagnosis of primary open angle glaucoma

Exclusion Criteria:

  • Primary open angle glaucoma combined with congenital ocular disease
  • Primary open angel glaucoma combined with other ocular disease
  • Significant systemic disease other than systemic hypertension and diabetes
Both
30 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
NCT01025024
CNUH81510-886, A080587
Yes
Chang-sik Kim, professor, Department of Ophthalmology, College of Medicine, Chungnam National University
Chungnam National University
  • Korea Healthcare Technology R&D Project
  • Korea Advanced Institute of Science and Technology
Principal Investigator: Chang-sik Kim, professor Department of Ophthalmology, Chungnam National University Hospital
Study Chair: Changwon Kang, professor Korea Advanced Institute of Science and Technology
Study Director: Kyunglan Kim Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Chungnam National University
December 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP