Role of Indoor Pollutants on House Dust Mite Allergic Asthma

This study has been withdrawn prior to enrollment.
Sponsor:
Information provided by:
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT01019291
First received: November 23, 2009
Last updated: July 27, 2011
Last verified: July 2011

November 23, 2009
July 27, 2011
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Complete list of historical versions of study NCT01019291 on ClinicalTrials.gov Archive Site
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Role of Indoor Pollutants on House Dust Mite Allergic Asthma
Aldehyde and Nitrogen Dioxide at Homes: Measurement of the Exposure and Their Role on Allergic Asthma

It seems that the aldehydes and NO2, at the levels found indoor, could be the aggravating factors for an allergic response. However this effect has not been demonstrated. The investigators plan to study the effect of exposure to standard doses of these pollutants on the bronchial reactivity as measured by bronchial challenge tests with dust mite extract in volunteers asthmatic, allergic to house dust mite.

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Interventional
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Allocation: Randomized
Masking: Double Blind (Subject, Investigator)
  • Allergic Asthma
  • Allergy to House Dust Mite
  • Other: Formaldehyde and NO2 (Exposure to indoor pollutants)
    Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract.
  • Other: Placebo (Exposure to indoor pollutants)
    Exposure to indoor pollutants (placebo) in a randomized way, followed by bronchial challenge test with house dust mite extract.
  • Experimental: NO2
    NO2 400 µg/m3
    Intervention: Other: Formaldehyde and NO2 (Exposure to indoor pollutants)
  • Experimental: Formaldehyde
    Formaldehyde 100 µg/m3
    Intervention: Other: Formaldehyde and NO2 (Exposure to indoor pollutants)
  • Experimental: NO2 + Formaldehyde
    mixture of Formaldehyde and NO2
    Intervention: Other: Formaldehyde and NO2 (Exposure to indoor pollutants)
  • Placebo Comparator: Placebo
    Intervention: Other: Placebo (Exposure to indoor pollutants)
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Withdrawn
25
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Inclusion criteria:

  • M/F 18-50 years of age
  • History of intermittent HDM allergic asthma-FEV1 > 80%
  • Non smokers or smokers with smoking < 10 PY

Exclusion criteria:

  • Persistent asthma and FEV1<80%
  • Allergic to pets and pets at home
Both
18 Years to 50 Years
No
Contact information is only displayed when the study is recruiting subjects
France
 
NCT01019291
3965
No
Christine GEILLER, Directeur de la Recherche Clinique et des Innovations, Hôpitaux Universitaires de Strasbourg
University Hospital, Strasbourg, France
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Principal Investigator: Frederic DE BLAY, MD Service de Pneumologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg
University Hospital, Strasbourg, France
July 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP