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Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise) (CEE)

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT00988299
First received: October 1, 2009
Last updated: December 2, 2011
Last verified: December 2011

October 1, 2009
December 2, 2011
October 2009
December 2011   (final data collection date for primary outcome measure)
non-exercise activity calorie expenditure [ Time Frame: 2 days after exercise sessions ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00988299 on ClinicalTrials.gov Archive Site
resting metabolic rate [ Time Frame: 2 days after exercise sessions ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise)
Energy Expenditure Responses to Acute Exercise in Older Women

In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:

  1. decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;
  2. increase in resting metabolic rate 48 hours after exercise;
  3. increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;
  4. decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.
Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Aging
Other: exercise
exercise sessions at 45% and 60% of maximum effort
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
26
December 2011
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Women
  2. Age 60-75 years
  3. normal weight
  4. Weight-stable (± 5%) within the previous 3 months
  5. Non-smoking for last year
  6. Able to provide own transportation to study visits
  7. Not currently involved in any other research study
  8. Willing and able to participate in all aspects of the trial including research testing
  9. Willing to give informed consent to participate

Exclusion Criteria:

  1. Self-reported significant cardiovascular disease
  2. Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
  3. Medications known to affect exercise performance or metabolism
  4. Excess caffeine use (> 500mg/day)
  5. Any self-reported contraindications to exercise
  6. Clinical depression
  7. Abnormal cognitive function -
Female
60 Years to 75 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00988299
09-0864, K99AG031297
No
Washington University School of Medicine
Washington University School of Medicine
National Institute on Aging (NIA)
Principal Investigator: Xuewen Wang, PhD Washington University School of Medicine
Washington University School of Medicine
December 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP