Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2012 by University of Aarhus.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00978640
First received: September 16, 2009
Last updated: June 19, 2012
Last verified: June 2012

September 16, 2009
June 19, 2012
September 2009
June 2012   (final data collection date for primary outcome measure)
Sirt1 activity [ Time Frame: 60 min ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00978640 on ClinicalTrials.gov Archive Site
secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover. [ Time Frame: 4 h ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise
Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Healthy
  • Other: fast and exercise
    fasting 36 h and exercise 1 h 50% VO2max
  • Other: exercise
    exercise 1 h 50% VO2max
  • Experimental: fasting and exercise
    36 h fast and 1 h ergometer cycling 50% VO2max
    Intervention: Other: fast and exercise
  • Experimental: exercise
    1 h ergometer cycling 50% VO2max
    Intervention: Other: exercise
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
8
June 2012
June 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • healthy men
  • Body mass index (BMI) 20-26
  • age 18-45 years

Exclusion Criteria:

  • any kind of disease
  • any use of medicine
Male
18 Years to 45 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00978640
07.09.2009
No
University of Aarhus
University of Aarhus
Not Provided
Not Provided
University of Aarhus
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP