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Correlation of Genetic Polymorphism and Livedo Vasculitis

This study has been completed.
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00975871
First received: September 11, 2009
Last updated: October 21, 2009
Last verified: October 2009

September 11, 2009
October 21, 2009
October 2007
April 2009   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00975871 on ClinicalTrials.gov Archive Site
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Correlation of Genetic Polymorphism and Livedo Vasculitis
Correlation of Genetic Polymorphism and Livedo Vasculitis

Livedo vasculitis is disease with recurrent courses of painful foot or ankle ulcerations, followed by healed white scars. The actual mechanism of its pathophysiology is not yet clear. It has been reported to be associated with some gene mutations, for example, factor V Leiden gene. This study is aimed to find the possible relation of these gene mutations in Taiwanese patients.

Livedo vasculitis is a chronic, recurrent painful ulcerations on the ankles and feet. This chronic disease is characterized by healed white, atrophic scars named atrophie blanche. The histopathological exam on the lesion site reveals fibrin deposition within the vessel walls. It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients. This study is trying to find the correlation between Taiwanese patients and these four genes.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Buccal mucosa cotton tip swab

Non-Probability Sample

General population

  • Livedo Vasculitis
  • Livedoid Vasculitis
  • Livedoid Vasculopathy
  • Genetic Pleomorphism
  • Leiden Mutation
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
50
April 2009
April 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Clinical diagnosis of livedo vasculitis

Exclusion Criteria:

  • No special exclusion criteria
Both
20 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT00975871
0961172000
Yes
Tsen-Fang Tsai/M.D, National Taiwan University Hospital
National Taiwan University Hospital
Not Provided
Principal Investigator: Tsen-Fang Tsai, MD National Taiwan University Hospital
National Taiwan University Hospital
October 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP