Effect of Radius on Alpha Motor Neuron Excitability (ERAMNE)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
ILHAN KARACAN, Vakif Gureba Training and Research Hospital
ClinicalTrials.gov Identifier:
NCT00961870
First received: August 14, 2009
Last updated: August 12, 2013
Last verified: August 2013

August 14, 2009
August 12, 2013
September 2009
November 2009   (final data collection date for primary outcome measure)
Changing alpha motor neuron excitability [ Time Frame: 1-2 months ] [ Designated as safety issue: No ]
Changing alpha motor neuron excitability [ Time Frame: 1 month or 2 months ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00961870 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Effect of Radius on Alpha Motor Neuron Excitability
Effect of Radius Subjecting to Mechanical Loading on Alpha Motor Neuron Excitability

This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density. If this hypothesis is valid, it can be firstly suggested that the relationship between bone mineral density and muscle strength is bidirectional.

A total of 80 voluntaries are planned to include in this study.

After forearm vibration is applied, bone mineral density (BMD) and bone mineral content (BMC) will be measured in all cases. Alpha motor neuron excitability (H/M ratio, recruitment), background muscle activity will be evaluated by electromyography at pre-treatment, post-treatment and, during treatment in cases.

Forearm vibration will be applied by forearm vibration device (FAV). FAV with mechanical loading will apply forearm. Cases will sit on armchair. Two intervals of FAV will be applied at a frequency of 45 Hz. Each interval will consist of 60 second of FAV followed by rest.

The right radius BMD and BMC will be evaluated by bone densitometer (GE-LUNAR DPX PRO).

Motor unite potentials at rest, Hoffman reflex, F response, M response will be measured by electromyography at right flexor carpi radialis. Medtronic Keypoint Portable 2 channel electromyography and Neurotrac ETS device will be used.

It is usually reported that there is a parallelism between changes in the bone structure and function and the muscle structure and function. Sarcopenia is frequently observed in osteoporotic patients. Bone formation increases or bone resorption decreases with exercise.

To date, the effect of bone on the muscle activity is not investigated. One of the most important functions of bone bear mechanical loads include body weight. Bone must be strong enough to resist the mechanical loading. Mechanisms need to protect bone when bone is subject to excessive mechanical loading. These mechanisms may mainly focus on strengthening the bone and/or changing vectorial properties of mechanical loading applied bone.

The vectorial properties of mechanical loading applied bone may be controlled by muscle contractions. Bone contains wide mechanoreceptor net constructed by osteocytes. So,distribution of the mechanical loading on bone cross-sectional area is possible to perceive. It may be also possible that inappropriate distribution of mechanical loading on bone crosssectional area is optimized by muscle contractions. To get this regulation, there should be a mechanism that muscle activity is controlled by central nervous system based on mechanical loading distribution on bone cross-sectional area. We previously showed that bone can regulate muscle activity, based on its bone mineral density. According to this study result, it can be suggested there may exist a mechanism that bone sensing mechanical stimuli can send the signals to central nervous system and neuronally regulate muscle activity (bone myo-regulation reflex). (It is also well known that load-induced adaptive bone formation is neuronally regulated. Taken together, a general mechanism, bone reflex, may be defined that bone subjected to loading can neuronally regulate bone formation and muscle activity)

This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density.

Interventional
Not Provided
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Basic Science
Osteoporosis
Procedure: Forearm vibration
Mechanical loading with forearm vibration will be applied right radius in all groups.
Other Name: Cyclic mechanical loading
  • Experimental: Healthy postmenopausal women
    Forearm vibration will be applied in women without postmenopausal osteoporosis
    Intervention: Procedure: Forearm vibration
  • Experimental: Osteoporotic postmenopausal women
    Forearm vibration will be applied in women with postmenopausal osteoporosis
    Intervention: Procedure: Forearm vibration
  • Experimental: Healthy young adult women
    Forearm vibration will be applied in healthy young adult women
    Intervention: Procedure: Forearm vibration
  • Experimental: Healthy young adult men
    Forearm vibration will be applied in healthy young adult men
    Intervention: Procedure: Forearm vibration
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
80
December 2009
November 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • females with postmenopausal osteoporosis (forearm BMD: T score <-2.0)
  • females without postmenopausal osteoporosis (forearm BMD: T score >-1.0)
  • healthy young adult females (forearm BMD normal)
  • healthy young adult males (forearm BMD normal)
  • cases with right handed patients in all groups

Exclusion Criteria:

  • secondary osteoporosis
  • neuropathy (central or peripheral)
  • myopathy
  • systemic diseases (arthritis, endocrine-metabolic diseases, bone diseases)
  • professional sportswoman/sportsman
  • subjects doing regular sports activities
  • tendinopathy
  • amputee, endoprosthesis, metal implants
Both
20 Years to 60 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Turkey
 
NCT00961870
VGEAH FTR-2
Yes
ILHAN KARACAN, Vakif Gureba Training and Research Hospital
Vakif Gureba Training and Research Hospital
Not Provided
Study Chair: ILHAN KARACAN, MD Vakif Gureba Training & Research Hospital
Vakif Gureba Training and Research Hospital
August 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP