Microbial Community Composition and Metabolism in Cystic Fibrosis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by Children's Hospital Boston.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
Massachusetts Institute of Technology
Harvard University
Information provided by:
Children's Hospital Boston
ClinicalTrials.gov Identifier:
NCT00954018
First received: August 5, 2009
Last updated: NA
Last verified: August 2009
History: No changes posted

August 5, 2009
August 5, 2009
August 2009
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No Changes Posted
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Microbial Community Composition and Metabolism in Cystic Fibrosis
Respiratory Microbial Community Composition and Metabolism in Cystic Fibrosis

Scientist have begun to realize that many types of bacteria often live together as a complex community, and the investigators wish to apply that idea to the bacteria in the respiratory system of people with Cystic Fibrosis (CF). It is possible that the survival of the many millions of bacteria in the CF lung depends on the production of special chemicals that might be made only by very few types of bacteria. If that is true, medicines that interfere with those chemicals could treat the lung infections that cause trouble for nearly all people with CF. The investigators wish to study the production of several potentially critical chemicals by the respiratory bacteria and to examine the effect of those chemicals on the makeup of the entire community of bacteria. To detect all the bacteria in that community, the investigators will use new methods that use bacterial genetic information and can detect hundreds of different types of bacteria in respiratory samples of individual CF patients.

Not Provided
Observational
Time Perspective: Prospective
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Retention:   Samples Without DNA
Description:

throat swabs or sputum

Non-Probability Sample

Cystic fibrosis patients will be contacted during clinical care visits and inpatient hospitalizations.

Cystic Fibrosis
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  • Cystic Fibrosis patient during outpatient clinic visit
  • Cystic Fibrosis patients during hospitalization
  • CF patients about to have sinus surgery and bronchoscopy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
120
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Inclusion Criteria:

  • confirmed diagnosis of Cystic Fibrosis
  • 2 to 55 years of age

Exclusion Criteria:

  • None
Both
2 Years to 55 Years
No
United States
 
NCT00954018
09-04-018
No
Thomas Martin, MD, Children's Hospital, Boston
Children's Hospital Boston
  • Massachusetts Institute of Technology
  • Harvard University
Not Provided
Children's Hospital Boston
August 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP