Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2012 by Yonsei University.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Hyuk-Jae Chang, Yonsei University
ClinicalTrials.gov Identifier:
NCT00917527
First received: June 9, 2009
Last updated: July 20, 2012
Last verified: July 2012

June 9, 2009
July 20, 2012
June 2009
November 2012   (final data collection date for primary outcome measure)
improvement of endothelial dysfunction with endo-PAT2000 [ Time Frame: 6 weeks later drug administration ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00917527 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease
Randomized Placebo-controlled Crossover Trial of Endothelial Function Improvement in Subjects With History of Premature Coronary Artery Disease

The aim of this prospective study is to investigate the prevalence of endothelial dysfunction in subjects with family history of premature coronary heart disease. At the same time, the effect of atorvastatin in treating subclinical endothelial dysfunction in those patients will be evaluated.

Not Provided
Interventional
Phase 4
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Coronary Heart Disease
Drug: Atorvastatin
Atorvastatin 40mg/D for 6 weeks to improve endothelial dysfunction
  • Placebo Comparator: Control
    Intervention: Drug: Atorvastatin
  • Experimental: Atorvastatin
    Intervention: Drug: Atorvastatin

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
77
June 2013
November 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • within 1 year
  • the siblings of premature coronary heart disease(male<55years old, female<65years old: Framingham Heart Study)patients admitted relevant hospital

Exclusion Criteria:

  • Documented coronary heart disease
  • Any woman of childbearing potential who is pregnant, seeking to become pregnant or suspects that she may be pregnant.
Both
18 Years and older
No
Contact: Hyuk-Jae Chang, MD, PhD 82-2-2228-8461 hjchang@yuhs.ac
Korea, Republic of
 
NCT00917527
20090615
Yes
Hyuk-Jae Chang, Yonsei University
Yonsei University
Not Provided
Principal Investigator: Hyuk-Jae Chang, MD, PhD Cardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine
Yonsei University
July 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP