Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants (GENBPD)

This study is enrolling participants by invitation only.
Sponsor:
Information provided by:
Centre Hospitalier Intercommunal Creteil
ClinicalTrials.gov Identifier:
NCT00904774
First received: May 19, 2009
Last updated: NA
Last verified: May 2009
History: No changes posted

May 19, 2009
May 19, 2009
May 2009
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bronchopulmonary dysplasia [ Time Frame: 36 weeks of postconceptional age ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
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Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants
Polymorphisms of Genes Controlling Alveolar Development and Risk of Bronchopulmonary Dysplasia

Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this disease must be found. BPD appears to result from arrested lung development, but its etiology has not yet been fully established. Besides the role of the exposure of the immature lung to injurious factors in the development of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking advantage of new genomic technologies, the objective of the investigators' project is to identify predisposing human genetic variants through:

  1. a genome-wide association (GWA) study in VLBW neonates,
  2. a candidate-gene association study, including selection of single nucleotide polymorphisms (SNPs) found in (a) and
  3. functional studies of any SNP found to be convincingly associated with BPD in (a) and (b).
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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

Premature neonates

Bronchopulmonary Dysplasia
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premature neonates
gestational age less than 28 weeks
Hadchouel A, Decobert F, Franco-Montoya ML, Halphen I, Jarreau PH, Boucherat O, Martin E, Benachi A, Amselem S, Bourbon J, Danan C, Delacourt C. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. PLoS ONE. 2008 Sep 11;3(9):e3188.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Enrolling by invitation
800
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Inclusion Criteria:

  • Gestational age < 28 weeks
  • Inborn birth
  • Prophylactic administration of surfactant in the delivery room
  • Written informed consent obtained from parents

Exclusion Criteria:

  • Gestational age of 28 weeks or more
  • Outborn birth
  • No prophylactic administration of surfactant in the delivery room
  • Congenital malformation
  • Absence of written informed consent obtained from parents
Both
up to 8 Weeks
No
Contact information is only displayed when the study is recruiting subjects
France
 
NCT00904774
AOR 07 018
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Delacourt, Christophe, MD, PhD, INSERM U955
Centre Hospitalier Intercommunal Creteil
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Centre Hospitalier Intercommunal Creteil
May 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP