Biomarkers in Patients With Head and Neck Cancer and in Healthy Volunteers

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2008 by National Cancer Institute (NCI).
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00899769
First received: May 9, 2009
Last updated: August 11, 2009
Last verified: October 2008

May 9, 2009
August 11, 2009
April 2005
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  • Differences in serum protein profiles and differences in the number of peptide matches [ Designated as safety issue: No ]
  • Protein levels and the largest difference in peptide matches in sera [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00899769 on ClinicalTrials.gov Archive Site
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Biomarkers in Patients With Head and Neck Cancer and in Healthy Volunteers
Serum Biomarkers for Head and Neck Cancer

RATIONALE: Studying samples of blood, tissue, and saliva in the laboratory from patients with cancer and from healthy volunteers may help doctors identify and learn more about biomarkers related to cancer.

PURPOSE: This laboratory study is looking at biomarkers in patients with head and neck cancer and in healthy volunteers.

OBJECTIVES:

  • Correlate the differences in serum protein profiles with the differences in the number of peptide matches in patients with squamous cell carcinoma of the head and neck and in healthy volunteers.
  • Correlate protein levels with the largest difference in peptide matches in sera in these participants.

OUTLINE: This is a prospective study.

Participants undergo blood, tissue, and saliva collection for biological studies. Samples are analyzed for albumin-bound and non-albumin-bound proteins or IgG via liquid chromatography and tandem mass spectrometry (LC-MS-MS), ELISA, proteomic profiling, and protein expression.

PROJECTED ACCRUAL: A total of 50 patients and 50 healthy volunteers will be accrued for this study.

Observational
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Head and Neck Cancer
  • Genetic: protein expression analysis
  • Genetic: proteomic profiling
  • Other: immunoenzyme technique
  • Other: laboratory biomarker analysis
  • Other: liquid chromatography
  • Other: mass spectrometry
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
100
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DISEASE CHARACTERISTICS:

  • Meets one of the following criteria:

    • Diagnosis of squamous cell carcinoma of the head and neck
    • Healthy volunteer matched by sex, race, birth decade, or smoking status (e.g., current smoker, former smoker, or nonsmoker)

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
Both
18 Years and older
Yes
United States
 
NCT00899769
CDR0000546781, VU-VICC-HN-0530, VU-VICC-IRB-050230
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Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)
Study Chair: Wendell G. Yarbrough, MD, FACS Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)
October 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP