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Study of Hair Samples From Patients With Cancer

This study has been completed.
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00899691
First received: May 9, 2009
Last updated: March 14, 2012
Last verified: March 2012
History of Changes

May 9, 2009
March 14, 2012
March 2005
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Obtain data on the detection and quantification of changes in levels of protein expression and phosphorylation status using human hair samples at baseline and after completion of study [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00899691 on ClinicalTrials.gov Archive Site
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Study of Hair Samples From Patients With Cancer
Detection and Quantification of Changes in Levels of Protein Expression and Phosphorylation Status Using Human Hair Samples

RATIONALE: Studying samples of hair in the laboratory from patients with cancer may help doctors identify biomarkers related to cancer and predict how well patients will respond to treatment.

PURPOSE: This laboratory study is looking at hair samples from patients with cancer.

OBJECTIVES:

  • Determine whether layered membrane technology can quantitatively measure the expression, activity, and localization of cell growth control and signaling proteins in hair samples from patients with cancer.
  • Correlate changes in protein expression with expected changes based on planned therapy in these patients.

OUTLINE: This is a pilot, multicenter study.

Hair samples are obtained from patients at baseline and at the end of study. The samples are assayed for proteins and phosphorylation status using layered membrane technology. Proteins analyzed may include vascular endothelial growth factor receptor (VEGFR), Erk1/2, Akt, epidermal growth factor receptor (EGFR), and c-KIT.

PROJECTED ACCRUAL: A total of 190 patients will be accrued for this study within 3 years.
Observational
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Unspecified Adult Solid Tumor, Protocol Specific
Genetic: protein expression analysis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
190
October 2008
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DISEASE CHARACTERISTICS:

  • Diagnosis of malignancy
  • Undergoing treatment at the National Cancer Institute's Clinical Center
  • Must have scalp hair

PATIENT CHARACTERISTICS:

Age

  • 18 and over

Performance status

  • Not specified

Life expectancy

  • Not specified

Hematopoietic

  • Not specified

Hepatic

  • Not specified

Renal

  • Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Not specified

Chemotherapy

  • Not specified

Endocrine therapy

  • Not specified

Radiotherapy

  • Not specified

Surgery

  • Not specified
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
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NCT00899691
040138, 04-C-0138, CDR0000363803
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National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)
Principal Investigator: Steven K. Libutti, MD NCI - Surgery Branch
National Institutes of Health Clinical Center (CC)
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP