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Bone Marrow and Blood Samples From Patients With Metastatic Choroid Melanoma

This study has been completed.
Sponsor:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00897624
First received: May 9, 2009
Last updated: May 12, 2011
Last verified: May 2011

May 9, 2009
May 12, 2011
November 2007
May 2011   (final data collection date for primary outcome measure)
Detection of micro-metastatic cells in 20 x 10^6 nucleated cells [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00897624 on ClinicalTrials.gov Archive Site
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Bone Marrow and Blood Samples From Patients With Metastatic Choroid Melanoma
Evaluation of the Detection of Tumor Cells in Bone Marrow and Blood in Patients With Choroid Melanoma

RATIONALE: Studying samples of bone marrow and blood from patients with cancer may help doctors find out the extent of disease.

PURPOSE: This research study is collecting bone marrow and blood samples from patients with metastatic choroid melanoma.

OBJECTIVES:

Primary

  • Develop and validate a method of detecting tumor cells in the bone marrow and blood in patients with metastatic choroid melanoma.

OUTLINE: While patients are under general anesthesia for standard treatment of their disease, samples of bone marrow from the iliac crest and blood are collected. Samples are analyzed for the expression of tyrosinase and Melan-a via RT-PCR.

Observational
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Intraocular Melanoma
  • Genetic: gene expression analysis
  • Genetic: reverse transcriptase-polymerase chain reaction
  • Other: laboratory biomarker analysis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
15
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May 2011   (final data collection date for primary outcome measure)

DISEASE CHARACTERISTICS:

  • Choroid melanoma

    • Metastatic disease
  • Planning to undergo general anesthesia

PATIENT CHARACTERISTICS:

  • Not pregnant or nursing
  • No contraindications to the collection of a bone marrow sample
  • No patient deprived of liberty or under trusteeship (including guardianship)
  • No social or psychological situations that preclude the ability to give consent

PRIOR CONCURRENT THERAPY:

  • Not specified
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
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NCT00897624
CDR0000633500, CLCC-IC-Micrometa-Melanome, CLCC-IC-2007-03, INCA-RECF0631
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Institut Curie
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Principal Investigator: Pierre T. Dorval, MD Institut Curie
National Cancer Institute (NCI)
May 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP