Protocol to Obtain Blood Samples for Leukemia Research
This study is currently recruiting participants.
Verified February 2013 by Dartmouth-Hitchcock Medical Center
Sponsor:
Dartmouth-Hitchcock Medical Center
Information provided by (Responsible Party):
Dartmouth-Hitchcock Medical Center
ClinicalTrials.gov Identifier:
NCT00889031
First received: April 24, 2009
Last updated: February 13, 2013
Last verified: February 2013
| Tracking Information | |||||||||
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| First Received Date ICMJE | April 24, 2009 | ||||||||
| Last Updated Date | February 13, 2013 | ||||||||
| Start Date ICMJE | April 2009 | ||||||||
| Estimated Primary Completion Date | April 2015 (final data collection date for primary outcome measure) | ||||||||
| Current Primary Outcome Measures ICMJE |
To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis. [ Time Frame: 2 Years ] [ Designated as safety issue: No ] | ||||||||
| Original Primary Outcome Measures ICMJE | Same as current | ||||||||
| Change History | Complete list of historical versions of study NCT00889031 on ClinicalTrials.gov Archive Site | ||||||||
| Current Secondary Outcome Measures ICMJE |
To determine whether suppression or inhibition of BCL2 family members can acutely sensitize CLL cells to vincristine. [ Time Frame: 2 Years ] [ Designated as safety issue: No ] | ||||||||
| Original Secondary Outcome Measures ICMJE | Same as current | ||||||||
| Current Other Outcome Measures ICMJE | Not Provided | ||||||||
| Original Other Outcome Measures ICMJE | Not Provided | ||||||||
| Descriptive Information | |||||||||
| Brief Title ICMJE | Protocol to Obtain Blood Samples for Leukemia Research | ||||||||
| Official Title ICMJE | Protocol to Obtain Blood Samples for Leukemia Research | ||||||||
| Brief Summary | The purpose of this study is to collect a blood sample in patients with Chronic Lymphocytic Leukemia (CLL). |
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| Detailed Description | The blood sample will be used in the laboratory to perform studies focusing on Chronic Lymphocytic Leukemia (CLL). |
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| Study Type ICMJE | Observational | ||||||||
| Study Design ICMJE | Observational Model: Cohort Time Perspective: Prospective |
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| Target Follow-Up Duration | Not Provided | ||||||||
| Biospecimen | Retention: Samples With DNA Description: 10cc of peripheral blood. |
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| Sampling Method | Non-Probability Sample | ||||||||
| Study Population | Patients at Dartmouth-Hitchcock Medical Center's Norris Cotton Cancer Center |
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| Condition ICMJE | Chronic Lymphocytic Leukemia | ||||||||
| Intervention ICMJE | Other: No Intervention
Patients with Chronic Lymphocytic Leukemia (CLL)
Other Name: No Intervention |
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| Study Group/Cohort (s) | No Treatment
Intervention: Other: No Intervention |
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| Publications * |
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* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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| Recruitment Information | |||||||||
| Recruitment Status ICMJE | Recruiting | ||||||||
| Estimated Enrollment ICMJE | 50 | ||||||||
| Estimated Completion Date | April 2015 | ||||||||
| Estimated Primary Completion Date | April 2015 (final data collection date for primary outcome measure) | ||||||||
| Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | 18 Years and older | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts ICMJE |
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| Location Countries ICMJE | United States | ||||||||
| Administrative Information | |||||||||
| NCT Number ICMJE | NCT00889031 | ||||||||
| Other Study ID Numbers ICMJE | D0905 | ||||||||
| Has Data Monitoring Committee | Yes | ||||||||
| Responsible Party | Dartmouth-Hitchcock Medical Center | ||||||||
| Study Sponsor ICMJE | Dartmouth-Hitchcock Medical Center | ||||||||
| Collaborators ICMJE | Not Provided | ||||||||
| Investigators ICMJE |
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| Information Provided By | Dartmouth-Hitchcock Medical Center | ||||||||
| Verification Date | February 2013 | ||||||||
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ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |
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