Activation of Hepatitis B Virus (HBV) in Hepatitis B Surface Antigen (HBsAg) - Negative But Hepatitis B Core Antibody (Anti-HBc) - Positive Patients

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2012 by Kyoto University
Sponsor:
Information provided by (Responsible Party):
Yoshihide Ueda, Kyoto University
ClinicalTrials.gov Identifier:
NCT00881036
First received: April 13, 2009
Last updated: September 25, 2012
Last verified: September 2012

April 13, 2009
September 25, 2012
August 2006
July 2016   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00881036 on ClinicalTrials.gov Archive Site
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Activation of Hepatitis B Virus (HBV) in Hepatitis B Surface Antigen (HBsAg) - Negative But Hepatitis B Core Antibody (Anti-HBc) - Positive Patients
Activation of HBV Under Immunosuppression in HBsAg-negative But Anti-HBc-positive Patients With Hematological Malignancies

Individuals with resolved hepatitis B, characterized as hepatitis B surface antigen (HBsAg)-negative and hepatitis B core antibody-positive, have latent hepatitis B virus (HBV) infection in their liver tissue. Cytotoxic chemotherapy and hematopoietic stem cell transplantation sometimes trigger the reactivation of latently infected HBV, resulting in de novo hepatitis B. Although de novo hepatitis B could cause acute liver failure or chronic hepatitis, an effective management strategy for de novo hepatitis B has not been well established. Risk factors and effective management for de novo hepatitis B will be clarified.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample

HBsAg-negative but anti-HBc-positive patients with hematological malignancies treated at Kyoto University Hospital

Hepatitis B
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
50
July 2018
July 2016   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • HBsAg-negative but anti-HBc-positive

Exclusion Criteria:

  • Serum HBV DNA-negative
Both
18 Years and older
No
Japan
 
NCT00881036
HBV from anti-HBc positive
No
Yoshihide Ueda, Kyoto University
Kyoto University
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Kyoto University
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP