Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index

• Blood Pressure [ Time Frame: 07/2010 ] [ Designated as safety issue: No ]
• Waist circumference [ Time Frame: 07/2010 ] [ Designated as safety issue: No ]

• Blood Pressure [ Time Frame: 03/2010 ] [ Designated as safety issue: No ]
• Waist circumference [ Time Frame: 03/2010 ] [ Designated as safety issue: No ]

Several environmental factors and comorbid conditions have been found to be associated with psoriasis in adults, including obesity, depression, smoking, and other cardiovascular risk factors such as high blood pressure. The object of this research study is to examine these associations in children as very little is known about psoriasis and cardiovascular risk factors in the pediatric population.

This is a multi-center study with a planned total enrollment of about 200 subjects ages 2-17 years old with psoriasis and 100 aged-match controls. Patient and family history will be recorded. All subjects will undergo standard height, weight, blood pressure, and waist circumference (WC). For the obese and overweight subjects we will also obtain their growth charts to attempt to correlate weight gain with psoriasis onset and progression. All data will be compiled and then statistically analyzed.

1. Children ages 5 to 17 years old with either moderate or severe plaque type psoriasis
2. Children ages 5 to 17 years old with moderate or severe atopic dermatitis
3. Children ages 5 to 17 years old seen in dermatology clinic who are healthy and without a systemic disorder.

• Psoriasis
• Atopic Dermatitis

• Other: Blood pressure
  Blood pressure will be measured once while patient is seated
• Other: Height
  Height will be measured in centimeters at the time of enrollment
• Other: Weight
  Weight will be measured in kilograms at enrollment
• Other: BMI
  Body Mass Index (BMI) will be calculated from a subject's height and weight
• Other: Waist Circumference
  Waist circumference will be measured midway between the lowest rib and the superior border of the iliac crest with an inelastic measuring tape at the end of normal expiration to the nearest 0.1cm

• Psoriasis
  Children ages 5-17 years old with moderate or severe plaque type psoriasis
  Interventions:

  • Other: Blood pressure
  • Other: Height
  • Other: Weight
  • Other: BMI
  • Other: Waist Circumference
• Atopic Dermatitis Controls
  Children ages 5 to 17 years old with moderate to severe atopic dermatitis.
  Interventions:

  • Other: Blood pressure
  • Other: Height
  • Other: Weight
  • Other: BMI
  • Other: Waist Circumference
• Healthy Controls
  Children 5-17 years of age who are healthy and seen in dermatology clinic for a non-systemic skin condition.
  Interventions:

  • Other: Blood pressure
  • Other: Height
  • Other: Weight
  • Other: BMI
  • Other: Waist Circumference

Inclusion Criteria:

• Subjects must be between the ages of 5 and 17 years at the time of enrollment.
• Subjects of either sex.
• Subjects who have had psoriatic plaques for more than 6 months.
• Subjects and guardians of minors must sign the approved IRB consent form(s) prior to initiation of the study protocol.
• Subjects enrolled as "non-inflammatory" normal controls will carry a common non- systemic skin condition, such as acne, nevi, warts and molluscum as their main diagnosis.
• Subjects enrolled as "inflammatory" normal controls will carry a diagnosis of moderate to severe atopic dermatitis.

Exclusion Criteria:

• Subjects who are unable to give informed consent or assent.
• Subjects who have had psoriasis for less than 6 months.
• Subjects whose condition is deemed unsafe or incapable by the study investigator for study participation.