Computer Stop Order Alert to Prevent Concurrent Prescribing of Trimethoprim/Sulfamethoxazole and Warfarin (warf-tmp/smx)

This study has been terminated.
(four adverse events encountered)
Sponsor:
Information provided by:
University of Pennsylvania
ClinicalTrials.gov Identifier:
NCT00870298
First received: March 26, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted

March 26, 2009
March 26, 2009
August 2006
January 2007   (final data collection date for primary outcome measure)
Reduce concomitant orders for warfarin and tmp/smx [ Time Frame: 7 months ] [ Designated as safety issue: Yes ]
Same as current
No Changes Posted
  • Determine if computerized stop order will increase risk for inadvertent cessation of warfarin [ Time Frame: 7 months ] [ Designated as safety issue: Yes ]
  • Determine if computerized stop order will increase risk of delay of treatment with tmp/sulfa when determined to be necessary for treatment [ Time Frame: 7 months ] [ Designated as safety issue: Yes ]
Same as current
Not Provided
Not Provided
 
Computer Stop Order Alert to Prevent Concurrent Prescribing of Trimethoprim/Sulfamethoxazole and Warfarin
Randomized Controlled Study of a Computer Stop Order Versus Routine Practice When Trimethoprim/Sulfamethoxazole is Ordered Concurrently With Warfarin

To determine if a computerized stop order will reduce the number of concurrent trimethoprim/sulfamethoxazole and warfarin orders accepted through the inpatient electronic ordering system while a patient is hospitalized.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Prescribers' Drug Orders
Drug: Trimethoprim/Sulfamethoxazole and Warfarin
  • Experimental: computerized alert
    An automatic electronic stop of the tmp/sulfa or warfarin order whenever a resident or nurse practitioner places an order for tmp/sulfa with an already active warfarin order, or when ordering both simultaneously
    Intervention: Drug: Trimethoprim/Sulfamethoxazole and Warfarin
  • 2 Current practice
    Current practice of the pharmacist recommending cessation of concurrent warfarin and tmp/sulfa orders
    Intervention: Drug: Trimethoprim/Sulfamethoxazole and Warfarin
Strom BL, Schinnar R, Aberra F, Bilker W, Hennessy S, Leonard CE, Pifer E. Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial. Arch Intern Med. 2010 Sep 27;170(17):1578-83.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
1971
January 2007
January 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

All resident physicians and nurse practitioners involved in inpatient care.

Exclusion Criteria:

None-

Both
Not Provided
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00870298
803788
No
Brian L. Strom, MD, MPH, UPenn
University of Pennsylvania
Not Provided
Not Provided
University of Pennsylvania
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP