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A Polymerase Chain Reaction (PCR) - Based Method to Improve Antibiotic Prescribing for Pneumonia

This study has suspended participant recruitment.
(funding issues)
Sponsor:
Collaborator:
The Physicians' Services Incorporated Foundation
Information provided by (Responsible Party):
Children's Hospital of Eastern Ontario
ClinicalTrials.gov Identifier:
NCT00867841
First received: March 23, 2009
Last updated: May 16, 2013
Last verified: June 2009

March 23, 2009
May 16, 2013
June 2009
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Complete list of historical versions of study NCT00867841 on ClinicalTrials.gov Archive Site
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A Polymerase Chain Reaction (PCR) - Based Method to Improve Antibiotic Prescribing for Pneumonia
A Polymerase Chain Reaction-based Method to Improve Antibiotic Prescribing for Children and Adolescents With Community-Acquired Pneumonia - a Pilot Study

Pneumonia, or lung infection, is usually treated with antibiotics targeted against the organisms that the physician guesses are causing the problem. The determination of the exact cause of a patient's pneumonia is difficult. The problem is that the two major causes of community-acquired pneumonia are not easily distinguished on clinical grounds and are best treated by different antibiotics. The investigators hypothesize that antibiotic therapy can be targeted and improved by doing polymerase chain reaction (PCR) testing of nose swabs to identify probable implicated organisms and their antibiotic resistance patterns. This pilot study will be important to ensure that the laboratory testing is functional and that the emergency department-laboratory communication is optimal prior to doing a full-fledged randomized clinical trial.

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Observational
Observational Model: Ecologic or Community
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

nasopharyngeal swabs blood samples (for pneumococcal PCR)

Non-Probability Sample

children with community-acquired pneumonia presenting to the Children's Hospital of Eastern Ontario emergency department

Pneumonia
Procedure: nasopharyngeal swab
PCR of NP swab for Mycoplasma, Chlamydophila, pneumococcus, pneumococcus macrolide resistance genes.
Pneumonia
Children diagnosed with community-acquired pneumonia by the emergency department physician
Intervention: Procedure: nasopharyngeal swab

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Suspended
100
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Inclusion Criteria:

  • presumed community-acquired pneumonia as diagnosed by the attending emergency department physician

Exclusion Criteria:

  • age > 6 months
  • immunodeficiency (primary, advanced HIV)
  • cystic fibrosis
  • malignancy
  • known cardiac or lung defects
  • bronchiectasis
  • previous pneumonia or lung abscess in past 6 months
  • conditions requiring treatment with immune suppressants
Both
180 Days and older
Yes
Contact information is only displayed when the study is recruiting subjects
Canada
 
NCT00867841
CHEO-ID-001
No
Children's Hospital of Eastern Ontario
Children's Hospital of Eastern Ontario
The Physicians' Services Incorporated Foundation
Principal Investigator: Jeffrey Pernica, MD Children's Hospital of Eastern Ontario/University of Ottawa
Study Director: Robert Slinger, MD Children's Hospital of Eastern Ontario/University of Ottawa
Children's Hospital of Eastern Ontario
June 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP