Retinol in Aged Skin

Topical therapy with retinoids is the only proven medical therapy for aged/photoaged human skin. However, topical therapy with retinoids often result in unwanted cutaneous dermatitis, including erythema and scaling. The reseachers intend to investigate the dose, frequency of use, and time dependence of topical retinol-induced dermatitis. The researchers intend to evaluate retinoid-induced dermatitis biochemically, including retinol regulation of retinoid responsive genes that control retinoid metabolism and serve as markers for retinoid bioactivity. The researchers will also investigate the role of EGF receptor pathway in retinoid-induced dermatitis.

Subjects will be between the ages of 50-60 years of age, with moderate clinical photodamage, and either gender.

• Aged Skin
• Photoaged Skin

• 1
  Subjects using 0.1% retinol one day per week
• 2
  Subjects using 0.1% retinol three days per week
• 3
  Subjects using 0.1% retinol seven days per week
• 4
  Subjects using 0.5% retinol one day per week
• 5
  Subjects using 0.5% retinol three days per week
• 6
  Subjects using 0.5% retinol seven times per week

Inclusion Criteria:

• Male or female
• Clinical photodamage, typically greater than 40 years of age
• Good general health
• No disease states, physical conditions or medications that would impair evaluation of the test sites
• Willingness and ability to follow protocol
• Signed written and witnessed informed consent form

Exclusion Criteria:

• Has received an experimental drug or used and experimental device in the 14 days prior to admission to the study
• History of keloids
• History of hypersensitivity to lidocaine or epinephrine
• Pregnant or nursing women
• Disease states or physical condition that would impair evaluation of the test sites or compliance with the protocol
• History of chemical peels or laser treatments to the sites evaluated